Chen Yang, Sun Lijie, Chen Minghui, Zhang Hui, Song Bing, Wang Hongxiao, Jiang Aijun, Zhang Li, Li Sumei, Wang Jumei, Wang Wei, Zhang Haoqiang
Department of Endocrinology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People's Republic of China.
Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Nov 25;17:4407-4415. doi: 10.2147/DMSO.S489204. eCollection 2024.
Our objective is to investigate the potential involvement of free triiodothyronine (FT3), a key bioactive compound found in thyroid hormones (THs) in the pathogenesis of diabetic peripheral neuropathy (DPN) in patients diagnosed with type 2 diabetes mellitus (T2DM).
A total of 121 T2DM patients were recruited. And then, they were divided into the control group and the DPN group. Clinical parameters were collected for each patient. Additionally, nerve conduction velocity was tested using neurophysiological methods. Correlation and regression analyses were employed to examine the relationship between the concentrations of FT3 and DPN.
Compared to 57 patients without DPN, 64 patients with DPN showed increased HbA1c and low-density lipoprotein cholesterol (LDL-C) levels (P=0.001 and 0.042), as well as decreased concentrations of FT3 (P=0.042). Additionally, FT3 levels are positively associated with the motor and sensory fibers conduction velocity of the Ulnar nerve, as well as the motor conduction velocity of the Tibial nerve, with (R=0.205, P=0.025; R=0.191, P=0.038; R=0.220, p=0.016) or without (R=0.257, P=0.004; R=0.227, P=0.012; R=0.227, p=0.012) adjustment for HbA1c and LDL-C. Furthermore, multiple linear regression analysis suggests that decreased FT3 levels may influence the motor and sensory fibers conduction velocity of the Ulnar nerve (β=0.795, P=0.025 and β=0.909, P=0.038), as well as the motor conduction velocity of the Tibial nerve (β=0.727, P=0.016). Moreover, our study demonstrated that decreased FT3 levels are one of the risk factors for DPN in T2DM patients, as determined by binary logistic regression analysis (OR=0.542, P=0.022).
Lower concentrations of FT3 are one of the risk factors for DPN in patients with T2DM. Additionally, decreased FT3 levels may influence peripheral neuropathy, particularly affecting the motor and sensory fibers conduction velocity of the ulnar nerve, as well as the motor fiber conduction velocity of the tibial nerve.
我们的目标是研究游离三碘甲状腺原氨酸（FT3），一种在甲状腺激素（THs）中发现的关键生物活性化合物，在2型糖尿病（T2DM）患者糖尿病周围神经病变（DPN）发病机制中的潜在作用。
共招募了121例T2DM患者。然后，将他们分为对照组和DPN组。收集每位患者的临床参数。此外，使用神经生理学方法测试神经传导速度。采用相关性和回归分析来检验FT3浓度与DPN之间的关系。
与57例无DPN的患者相比，64例有DPN的患者糖化血红蛋白（HbA1c）和低密度脂蛋白胆固醇（LDL-C）水平升高（P = 0.001和0.042），以及FT3浓度降低（P = 0.042）。此外，FT3水平与尺神经的运动和感觉纤维传导速度以及胫神经的运动传导速度呈正相关，在调整或未调整HbA1c和LDL-C的情况下，分别为（R = 0.205，P = 0.025；R = 0.191，P = 0.038；R = 0.220，p = 0.016）或（R = 0.257，P = 0.004；R = 0.227，P = 0.012；R = 0.227，p = 0.012）。此外，多元线性回归分析表明，FT3水平降低可能影响尺神经的运动和感觉纤维传导速度（β = 0.795，P = 0.025和β = 0.909，P = 0.038），以及胫神经的运动传导速度（β = 0.727，P = 0.016）。此外，我们的研究表明，通过二元逻辑回归分析确定，FT3水平降低是T2DM患者发生DPN的危险因素之一（OR = 0.542，P = 0.022）。
较低的FT3浓度是T2DM患者发生DPN的危险因素之一。此外，FT3水平降低可能影响周围神经病变，尤其影响尺神经的运动和感觉纤维传导速度以及胫神经的运动纤维传导速度。
