Zhang Xi, Shen Xiurong, Zhou Wan, Xu Mengyun, Xing Yan, Weng Jianping, Ye Shandong, Xu Suowen, Zhang Zhi, Wang Wei
Department of Endocrinology and Laboratory for Diabetes, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People's Republic of China.
Graduate School, Wannan Medical College, Wuhu, Anhui, People's Republic of China.
Endocr Connect. 2021 Nov 3;10(11):1403-1409. doi: 10.1530/EC-21-0290.
A variety of studies have demonstrated the role of lipocalin 2 (LCN2) in both diabetes and neurological disorders. Nevertheless, the relationship between LCN2 and diabetic peripheral neuropathy (DPN) needs to be elucidated in humans. Therefore, this study aimed to investigate the association of LCN2 with DPN in type 2 diabetes (T2D). A total of 207 participants with T2D and 40 participants with normal glucose tolerance (NGT) were included in this study. All participants were classified into DPN group and non-DPN (NDPN) group based on the Toronto Clinical Neuropathy Scoring (TCNS). Demographic and biochemical parameters were measured. Serum LCN2 levels were determined using an ELISA technique. Serum LCN2 levels in NGT group were lower than those in either DPN group (P = 0.000) or NDPN group (P = 0.043), while serum LCN2 levels in DPN group were higher than NDPN group (P = 0.001). Moreover, serum LCN2 levels positively correlated to TCNS scores, which reflects neuropathy severity (r = 0.438, P = 0.000). Multivariate stepwise regression analysis showed that BMI, triglycerides, and diastolic pressure were independently associated with serum LCN2 in DPN. Additionally, logistic regression analysis demonstrated that LCN2 (odds ratio (OR) = 1.009) and diabetes duration (OR = 1.058) were independently associated with the occurrence of DPN in T2D. Our report reveals the association of serum LCN2 with DPN in T2D. LCN2 might be used to evaluate DPN severity and serve a role in the pathogenesis of DPN.
多项研究已证明脂质运载蛋白2（LCN2）在糖尿病和神经系统疾病中均起作用。然而，LCN2与糖尿病性周围神经病变（DPN）之间的关系尚需在人体中阐明。因此，本研究旨在探讨LCN2与2型糖尿病（T2D）患者DPN的相关性。本研究共纳入207例T2D患者和40例糖耐量正常（NGT）者。所有参与者根据多伦多临床神经病变评分（TCNS）分为DPN组和非DPN（NDPN）组。测量了人口统计学和生化参数。采用酶联免疫吸附测定（ELISA）技术测定血清LCN2水平。NGT组血清LCN2水平低于DPN组（P = 0.000）和NDPN组（P = 0.043），而DPN组血清LCN2水平高于NDPN组（P = 0.001）。此外，血清LCN2水平与反映神经病变严重程度的TCNS评分呈正相关（r = 0.438，P = 0.000）。多因素逐步回归分析显示，体重指数、甘油三酯和舒张压与DPN患者血清LCN2独立相关。此外，逻辑回归分析表明，LCN2（比值比（OR）= 1.009）和糖尿病病程（OR = 1.058）与T2D患者DPN的发生独立相关。我们的报告揭示了血清LCN2与T2D患者DPN的相关性。LCN2可能用于评估DPN的严重程度，并在DPN的发病机制中起作用。
