Wang Wei, Meng Liu, Hu Zheyu, Yuan Xia, Zeng Weisi, Li Kunlun, Luo Hanjia, Tang Min, Zhou Xiao, Tian Xiaoqiong, Luo Chenhui, He Yi, Yang Shuo
Gastroenterology and Urology Department II, Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Gastroenterology and Urology Department II, Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine, Clinical Research Center For Gastrointestinal Cancer In Hunan Province, Changsha, China.
Front Oncol. 2022 Sep 29;12:939564. doi: 10.3389/fonc.2022.939564. eCollection 2022.
There is a positive association between air pollution and lung cancer burden. This study aims to identify and examine lung cancer risks and mortality burdens associated with air pollutants, including PM, NO and SO, in seven eastern metropolises of China. The study population comprised a population from seven eastern metropolises of China. The yearly average values (YAV, μg/m) of the PM, NO and SO levels were extracted from China Statistical Yearbook (CSYB) for each selected city from 2006 to 2014. Data collected in the China Cancer Registry Annual Report (CCRAR) provide lung cancer incidence and mortality information. A two-level normal random intercept regression model was adopted to analyze the association between the lung cancer rates and individual air pollutant concentration within a five-year moving window of past exposure. The yearly average values of PM10, SO2 and NO2 significantly decreased from 2006 to 2014. Consistently, the male age-adjusted incidence rate (MAIR) and male age-adjusted mortality rate (MAMR) decreased significantly from 2006 to 2014.Air pollutants have a lag effect on lung cancer incidence and mortality for 2-3 years. NO2 has the significant association with MAIR (RR=1.57, 95% CI: 1.19-2.05, p=0.002), MAMR (RR=1.70, 95% CI: 1.32-2.18, p=0.0002) and female age-adjusted mortality rate (FAMR) (RR=1.27, 95% CI: 1.08-1.49, p=0.003). Our findings suggested that air pollutants may be related to the occurrence and mortality of lung cancer. NO2 was significantly associated with the risk of lung cancer, followed by SO2. Air pollutants have the strongest lag effect on the incidence and mortality of lung cancer within 2-3 years.
空气污染与肺癌负担之间存在正相关关系。本研究旨在识别和检验中国东部七个大都市中与空气污染物（包括颗粒物、氮氧化物和二氧化硫）相关的肺癌风险和死亡负担。研究人群包括来自中国东部七个大都市的人口。从《中国统计年鉴》（CSYB）中提取了2006年至2014年每个选定城市的颗粒物、氮氧化物和二氧化硫水平的年平均值（YAV，μg/m³）。《中国癌症登记年报》（CCRAR）收集的数据提供了肺癌发病率和死亡率信息。采用二级正态随机截距回归模型分析过去暴露的五年移动窗口内肺癌发病率与个体空气污染物浓度之间的关联。2006年至2014年，PM10、SO2和NO2的年平均值显著下降。同样，2006年至2014年，男性年龄调整发病率（MAIR）和男性年龄调整死亡率（MAMR）显著下降。空气污染物对肺癌发病率和死亡率有2至3年的滞后效应。NO2与MAIR（RR = 1.57，95%CI：1.19 - 2.05，p = 0.002）、MAMR（RR = 1.70，95%CI：1.32 - 2.18，p = 0.0002）和女性年龄调整死亡率（FAMR）（RR = 1.27，95%CI：1.08 - 1.49，p = 0.003）有显著关联。我们的研究结果表明，空气污染物可能与肺癌的发生和死亡率有关。NO2与肺癌风险显著相关，其次是SO2。空气污染物在2至3年内对肺癌的发病率和死亡率具有最强的滞后效应。
