Halfmann Moritz C, Luetkens Julian A, Langenbach Isabel L, Kravchenko Dmitrij, Wenzel Philip, Emrich Tilman, Isaak Alexander
Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg-University Mainz, 55116 Mainz, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 55116 Mainz, Germany.
Diagnostics (Basel). 2023 Jun 26;13(13):2172. doi: 10.3390/diagnostics13132172.
Persistent or recurrent cardiovascular symptoms have been identified as one of the hallmarks of long-COVID or post-acute sequelae of SARS-CoV-2 infection (PASC). The purpose of this study was to determine the prevalence and extent of cardiac abnormalities in patients referred for cardiac MRI due to clinical evidence of PASC. To investigate this, two tertiary care hospitals identified all patients who were referred for cardiac MRI under the suspicion of PASC in a 2-year period and retrospectively included them in this study. Patients with previously known cardiac diseases were excluded. This resulted in a total cohort of 129 patients (63, 51% female; age 41 ± 16 years). The majority of patients (57%) showed normal cardiac results. No patient had active myocarditis or an acute myocardial infarction. However, 30% of patients had evidence of non-ischemic myocardial fibrosis, which exceeds the prevalence in the normal adult population and suggests that a possible history of myocarditis might explain persistent symptoms in the PASC setting.
持续性或复发性心血管症状已被确定为新冠长期症状或新冠病毒2感染后急性后遗症（PASC）的标志之一。本研究的目的是确定因PASC临床证据而接受心脏磁共振成像（MRI）检查的患者中心脏异常的患病率和程度。为了对此进行调查，两家三级护理医院确定了在两年内因疑似PASC而被转诊进行心脏MRI检查的所有患者，并将他们回顾性纳入本研究。排除既往已知患有心脏病的患者。这产生了一个由129名患者组成的队列（63名，51%为女性；年龄41±16岁）。大多数患者（57%）的心脏检查结果正常。没有患者患有活动性心肌炎或急性心肌梗死。然而，30%的患者有非缺血性心肌纤维化的证据，这超过了正常成年人群的患病率，表明心肌炎的可能病史可能解释了PASC情况下的持续症状。
