Kim Sul-Ki, Lee Nam-Hun, Son Chang-Gue
Liver and Immunology Research Center, Collage of Korean Medicine, Daejeon University, Daejeon 35235, Republic of Korea.
East-West Cancer Center, Cheonan Korean Medicine Hospital, Daejeon University, Cheonan 31099, Republic of Korea.
Cancers (Basel). 2023 Jun 29;15(13):3415. doi: 10.3390/cancers15133415.
Liver metastases remain a major obstacle for the management of all types of tumors arising from digestive organs, and the tumor microenvironment has been regarded as an important factor in metastasis. To discover herbal candidates inhibiting the liver metastasis of tumors originating from the digestive system via the modulation of the tumor microenvironment and liver environment, we searched three representative public databases and conducted a systematic review. A total of 21 studies that employed experimental models for pancreatic (9), colon (8), and stomach cancers (4) were selected. The herbal agents included single-herb extracts (5), single compounds (12), and multiherbal decoctions (4). was most frequently studied for its anti-colon-liver metastatic effects, and its possible mechanisms involved the modulation of tumor microenvironment components such as vascular endothelial cells and immunity in both tumor tissues and circulating cells. The list of herbal agents and their mechanisms produced in this study is helpful for the development of anti-liver metastasis drugs in the future.
肝转移仍然是消化系统各类肿瘤治疗中的主要障碍，肿瘤微环境被认为是转移的一个重要因素。为了通过调节肿瘤微环境和肝脏环境来发现抑制源自消化系统肿瘤肝转移的草药候选物，我们检索了三个具有代表性的公共数据库并进行了系统综述。总共选择了21项采用胰腺癌（9项）、结肠癌（8项）和胃癌（4项）实验模型的研究。草药制剂包括单味草药提取物（5种）、单一化合物（12种）和多味草药煎剂（4种）。 因其抗结肠-肝转移作用而被研究得最为频繁，其可能的机制涉及调节肿瘤微环境成分，如肿瘤组织和循环细胞中的血管内皮细胞和免疫。本研究中产生的草药制剂及其作用机制列表有助于未来抗肝转移药物的开发。
