Mkuu Rahma S, Hall Jaclyn M, Galochkina Zhanna, Cho Hee Deok, Staras Stephanie A S, Lee Ji-Hyun, Guo Yi, Chakrabarti Choeeta, Barrow Sable Bowman, Ortega Selena, Avery Daniel M, Higginbotham John, Lockhart Jala, Shenkman Elizabeth A
Department of Health Science, The University of Alabama, Tuscaloosa, AL 35487, USA.
Department of Health Outcomes and Biomedical Informatics, The University of Florida, 2199 Mowry Road, Gainesville, FL 32611, USA.
Healthcare (Basel). 2023 Jun 27;11(13):1863. doi: 10.3390/healthcare11131863.
Cervical cancer and Type 2 Diabetes (T2D) share common demographic risk factors. Despite this, scarce research has examined the relationship between race/ethnicity, having T2D, and cervical cancer incidence. We analyzed statewide electronic health records data between 2012 and 2019 from the OneFlorida+ Data Trust. We created a 1:4 nested case-control dataset. Each case (patient with cervical cancer) was matched with four controls (patients without cervical cancer) without replacement by year of encounter, diagnosis, and age. We used conditional logistic regression to estimate the unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to examine the association between race/ethnicity, T2D, and cervical cancer incidence. A total of 100,739 cases and 402,956 matched controls were identified. After adjusting for sociodemographic characteristics, non-Hispanic Black women with T2D had higher odds of cervical cancer compared with non-Hispanic White women with T2D (OR: 1.58, 95% CI 1.41-1.77). Living in a rural area, having Medicaid/Medicare insurance, and having high social vulnerability were associated with higher odds of having a cervical cancer diagnosis. Our findings imply the need to address the higher burden of cervical cancer diagnosis among non-Hispanic Black women with T2D and in underserved populations.
宫颈癌和2型糖尿病（T2D）有共同的人口统计学风险因素。尽管如此，针对种族/民族、患有T2D与宫颈癌发病率之间关系的研究却很少。我们分析了来自OneFlorida+数据信托的2012年至2019年全州电子健康记录数据。我们创建了一个1:4的巢式病例对照数据集。每个病例（宫颈癌患者）与四个对照（无宫颈癌患者）进行匹配，匹配时不重复，匹配因素包括就诊年份、诊断和年龄。我们使用条件逻辑回归来估计未调整和调整后的比值比（OR）以及95%置信区间（CI），以检验种族/民族、T2D与宫颈癌发病率之间的关联。共识别出100739例病例和402956例匹配对照。在调整了社会人口学特征后，患有T2D的非西班牙裔黑人女性患宫颈癌的几率高于患有T2D的非西班牙裔白人女性（OR：1.58，95%CI 1.41 - 1.77）。生活在农村地区、拥有医疗补助/医疗保险以及社会脆弱性高与宫颈癌诊断几率较高相关。我们的研究结果表明，需要解决患有T2D的非西班牙裔黑人女性以及服务不足人群中宫颈癌诊断负担较高的问题。
