Abonyi-Tóth Zsolt, Rokszin György, Sütő Gábor, Fábián Ibolya, Kiss Zoltán, Jermendy György, Kempler Péter, Lengyel Csaba, Wittmann István, Molnár Gergő A
RxTarget Ltd., 5000 Szolnok, Hungary.
Department of Biostatistics, University of Veterinary Medicine, 1078 Budapest, Hungary.
Cancers (Basel). 2024 Jun 29;16(13):2414. doi: 10.3390/cancers16132414.
(1) Background: Among the chronic complications of type 2 diabetes mellitus, cancer has become the leading cause of death in several countries. Our objective was to determine whether prevalent type 2 diabetes mellitus is associated with a higher incidence of cancer. (2) Methods: This study comprised a nationwide analysis conducted in Hungary. The study population was divided into two groups: a type 2 diabetes mellitus group vs. a non-diabetic group. The primary outcome was the risk related to overall cancer incidence; a key secondary outcome was the overall incidence of cancer in distinct study years; and a further outcome was the annual percent changes. (3) Results: The odds ratio related to the overall incidence of cancer was 2.50 (95% confidence interval: 2.46-2.55, < 0.0001) in patients with diabetes as related to non-diabetic controls. The odds ratio was higher in males than in females [OR: 2.76 (2.70-2.82) vs. OR: 2.27 (2.22-2.33), < 0.05 for male-to-female comparison]. The annual cancer incidence rate declined in non-diabetic controls, but not in patients with diabetes [-1.79% (-2.07--1.52%), < 0.0001] vs. -0.50% (-1.12-+0.10%), = 0.0991]. Several types of cancer showed a decreasing tendency in non-diabetic controls, but not in patients with type 2 diabetes. (4) Conclusions: Type 2 diabetes is associated with a higher risk of cancer. While the cancer incidence decreased for non-diabetic individuals with time, it remained unchanged in patients with T2DM.
(1) 背景：在2型糖尿病的慢性并发症中，癌症已成为多个国家的主要死因。我们的目的是确定2型糖尿病的流行是否与癌症发病率较高相关。(2) 方法：本研究包括在匈牙利进行的一项全国性分析。研究人群分为两组：2型糖尿病组和非糖尿病组。主要结局是与总体癌症发病率相关的风险；一个关键的次要结局是不同研究年份的癌症总体发病率；另一个结局是年度百分比变化。(3) 结果：与非糖尿病对照组相比，糖尿病患者总体癌症发病率的比值比为2.50（95%置信区间：2.46 - 2.55，<0.0001）。男性的比值比高于女性[比值比：2.76（2.70 - 2.82）对比值比：2.27（2.22 - 2.33），男性与女性比较，P<0.05]。非糖尿病对照组的年度癌症发病率下降，但糖尿病患者未下降[-1.79%（-2.07 - -1.52%），P<0.0001] 对比 -0.50%（-1.12 - +0.10%），P = 0.0991]。几种类型的癌症在非糖尿病对照组中呈下降趋势，但在2型糖尿病患者中未下降。(4) 结论：2型糖尿病与较高的癌症风险相关。虽然非糖尿病个体的癌症发病率随时间下降，但2型糖尿病患者的发病率保持不变。
