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用于低密度脂蛋白吸附的葡聚糖/磺化聚砜共混膜的制备与研究

Fabrication and Study of Dextran/Sulfonated Polysulfone Blend Membranes for Low-Density Lipoprotein Adsorption.

作者信息

Fang Fei, Zhao Hai-Yang, Wang Rui, Chen Qi, Wang Qiong-Yan, Zhang Qing-Hua

机构信息

College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Research and Development Center, Zhejiang Sucon Silicone Co., Ltd., Shaoxing 312088, China.

出版信息

Materials (Basel). 2023 Jun 27;16(13):4641. doi: 10.3390/ma16134641.

DOI:10.3390/ma16134641
PMID:37444954
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10342430/
Abstract

The abnormal increase in low-density lipoprotein (LDL) in human blood is a main independent risk factor for the pathogenesis of atherosclerosis, whereas a reduced LDL level effectively lowers morbidity. It is important to develop LDL adsorption materials with high efficiency and selectivity, as well as to simplify their fabrication processes. In this paper, polysulfone (PSF), sulfonated polysulfone (SPSF), and sulfonated polysulfone/dextran (SPSF/GLU) membranes were successfully fabricated for LDL adsorption using a solution casting technique. Attenuated total reflectance Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy measurements confirmed the success of the preparation. The water contact angle decreased from 89.7 ± 3.4° (PSF) to 76.4 ± 3.2° (SPSF) and to 71.2 ± 1.9° (SPSF/GLU), respectively. BSA adsorption testing showed that the SPSF/GLU with surface enrichment of sulfonate groups and glycosyl groups possessed higher resistance to protein solution. The adsorption and desorption behaviors of the studied samples in single-protein or binary-protein solutions were systematically investigated by enzyme-linked immunosorbent assay (ELISA), The results showed that SPSF/GLU, which had excellent resistance to protein adsorption, possessed a similar adsorption capacity to that of PSF. SPSF membrane exhibited excellent selective affinity for LDL in single and binary protein solutions, suggesting potential applications in LDL removal.

摘要

人体血液中低密度脂蛋白（LDL）异常升高是动脉粥样硬化发病机制的主要独立危险因素，而降低LDL水平可有效降低发病率。开发高效、选择性高的LDL吸附材料并简化其制备工艺具有重要意义。本文采用溶液浇铸技术成功制备了用于LDL吸附的聚砜（PSF）、磺化聚砜（SPSF）和磺化聚砜/葡聚糖（SPSF/GLU）膜。衰减全反射傅里叶变换红外光谱和X射线光电子能谱测量证实了制备的成功。水接触角分别从89.7±3.4°（PSF）降至76.4±3.2°（SPSF）和71.2±1.9°（SPSF/GLU）。牛血清白蛋白吸附测试表明，表面富含磺酸基团和糖基的SPSF/GLU对蛋白质溶液具有更高的抗性。通过酶联免疫吸附测定（ELISA）系统研究了所研究样品在单蛋白或双蛋白溶液中的吸附和解吸行为，结果表明，对蛋白质吸附具有优异抗性的SPSF/GLU具有与PSF相似的吸附能力。SPSF膜在单蛋白和双蛋白溶液中对LDL表现出优异的选择性亲和力，表明其在去除LDL方面具有潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/2028c0d2bec5/materials-16-04641-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/83e3e55e8324/materials-16-04641-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/8815f7e06f3d/materials-16-04641-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/b800bab0d4bc/materials-16-04641-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/87b74e3e3cc0/materials-16-04641-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/debc5a5cce04/materials-16-04641-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/7ea2a96fdf0e/materials-16-04641-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/20f7efcf43de/materials-16-04641-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/17775b920422/materials-16-04641-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/2028c0d2bec5/materials-16-04641-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/83e3e55e8324/materials-16-04641-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/8815f7e06f3d/materials-16-04641-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/b800bab0d4bc/materials-16-04641-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/87b74e3e3cc0/materials-16-04641-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/debc5a5cce04/materials-16-04641-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/7ea2a96fdf0e/materials-16-04641-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/20f7efcf43de/materials-16-04641-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/17775b920422/materials-16-04641-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d292/10342430/2028c0d2bec5/materials-16-04641-g009.jpg

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Fabrication and Study of Dextran/Sulfonated Polysulfone Blend Membranes for Low-Density Lipoprotein Adsorption.

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引用本文的文献

[1]
Facile Preparation of β-Cyclodextrin-Modified Polysulfone Membrane for Low-Density Lipoprotein Adsorption via Dopamine Self-Assembly and Schiff Base Reaction.

Materials (Basel). 2024-2-21

本文引用的文献

[1]
Simple emulsion template method towards self-anticoagulant and high-efficiency carboxymethyl chitosan-based adsorbent for low-density lipoprotein from whole blood.

J Colloid Interface Sci. 2023-2

[2]
An update on lipid apheresis for familial hypercholesterolemia.

Pediatr Nephrol. 2023-2

[3]
Amphiphilic Alginate-Based Layer-by-Layer Coatings Exhibiting Resistance against Nonspecific Protein Adsorption and Marine Biofouling.

ACS Appl Mater Interfaces. 2022-4-13

[4]
Biomembrane-mimetic hemoperfusion adsorbent for efficient removal of low-density lipoprotein from hyperlipemia blood.

J Biomed Mater Res B Appl Biomater. 2022-8

[5]
Control of Specific/Nonspecific Protein Adsorption: Functionalization of Polyelectrolyte Multilayer Films as a Potential Coating for Biosensors.

Materials (Basel). 2021-12-11

[6]
New and emerging lipid-modifying drugs to lower LDL cholesterol.

Drugs Context. 2021-11-1

[7]
Bio-inspired dual-functional phospholipid-poly(acrylic acid) brushes grafted porous poly(vinyl alcohol) beads for selective adsorption of low-density lipoprotein.

J Mater Chem B. 2021-8-28

[8]
Selective Molecular Recognition of Low Density Lipoprotein Based on β-Cyclodextrin Coated Electrochemical Biosensor.

Biosensors (Basel). 2021-6-30

[9]
Rapid separation of blood plasma exosomes from low-density lipoproteins via a hydrophobic interaction chromatography method on a polyester capillary-channeled polymer fiber phase.

Anal Chim Acta. 2021-7-4

[10]
Chondroitin sulfate-enriched hierarchical multichannel polydopamine nanoparticles with ultrahigh sorption capacity for separation of low-density lipoprotein.

J Mater Chem B. 2021-3-4

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