Beebeejaun Yusuf, Copeland Timothy, Polanski Lukasz, El Toukhy Tarek
Department of Women's Health, Faculty of Life Sciences and Medicine, King's College London, London WC2R 2LS, UK.
Assisted Conception Unit, Guy's and St Thomas' Hospital, London SE1 9RT, UK.
J Clin Med. 2023 Jun 21;12(13):4172. doi: 10.3390/jcm12134172.
The ability to predict the likelihood of a live birth after single fresh embryo transfer is an important part of fertility treatment. While past studies have examined the likelihood of live birth based on the number of oocytes retrieved and cleavage-stage embryos available, the odds of a live birth based on the number of supernumerary blastocysts cryopreserved following a fresh embryo transfer has not been rigorously studied. We performed a retrospective analysis, stratified by age, on patients undergoing their first fresh autologous single day 5 blastocyst transfer to assess relationship between the likelihood of a live birth and number of supernumerary blastocysts cryopreserved. In patients aged <35 years and 35-39 years old, the likelihood of a live birth increased linearly between 1 and 6 supplementary blastocysts and non-linearly if 10 or more blastocysts were cryopreserved. When aged 40 years and above, the likelihood of a live birth increased linearly up to 4 cryopreserved blastocysts and then non-linearly if 10 or more blastocysts were cryopreserved. The present study demonstrated a non-linear relationship between the number of supernumerary blastocysts cryopreserved and the likelihood of a live birth after single blastocyst transfer in the first autologous fresh IVF/ICSI cycle across different age groups.
预测单次新鲜胚胎移植后活产可能性的能力是生育治疗的重要组成部分。虽然过去的研究已经根据获取的卵母细胞数量和可用的卵裂期胚胎来研究活产的可能性，但基于新鲜胚胎移植后冷冻保存的多余囊胚数量的活产几率尚未得到严格研究。我们对接受首次新鲜自体第5天囊胚移植的患者进行了一项按年龄分层的回顾性分析，以评估活产可能性与冷冻保存的多余囊胚数量之间的关系。在年龄小于35岁和35 - 39岁的患者中，活产可能性在1至6个补充囊胚之间呈线性增加，而如果冷冻保存10个或更多囊胚则呈非线性增加。在年龄40岁及以上的患者中，活产可能性在冷冻保存4个囊胚之前呈线性增加，而如果冷冻保存10个或更多囊胚则呈非线性增加。本研究表明，在首次自体新鲜体外受精/卵胞浆内单精子注射周期中，不同年龄组冷冻保存的多余囊胚数量与单次囊胚移植后活产可能性之间存在非线性关系。
