Bozsányi Szabolcs, Czurkó Natália, Becske Melinda, Kasek Roland, Lázár Botond Keve, Boostani Mehdi, Meznerics Fanni Adél, Farkas Klára, Varga Noémi Nóra, Gulyás Lili, Bánvölgyi András, Fehér Bence Ágoston, Fejes Emese, Lőrincz Kende, Kovács Anikó, Gergely Hunor, Takács Szabolcs, Holló Péter, Kiss Norbert, Wikonkál Norbert, Lázár Imre
Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary.
J Clin Med. 2023 Jun 21;12(13):4194. doi: 10.3390/jcm12134194.
Each brain hemisphere plays a specialized role in cognitive and behavioral processes, known as hemispheric lateralization. In chronic skin diseases, such as plaque psoriasis (Pso) and atopic dermatitis (AD), the degree of lateralization between the frontal hemispheres may provide insight into specific connections between skin diseases and the psyche. This study aims to analyze the hemispherical lateralization, neurovegetative responses, and psychometric characteristics of patients with Pso and AD.
The study included 46 patients with Pso, 56 patients with AD, and 29 healthy control (Ctrl) subjects. The participants underwent frontal electroencephalogram (EEG) measurement, heart rate variability (HRV) assessment, and psychological tests. Statistical analyses were performed using ANOVA, with Bonferroni correction applied for multiple comparisons.
This study shows a significant right-lateralized prefrontal activity in both AD patients ( < 0.001) and Pso patients ( = 0.045) compared with Ctrl, with no significant difference between the AD and Pso groups ( = 0.633). AD patients with right-hemispheric dominant prefrontal activation exhibited increased inhibition and avoidance markers, while Pso patients showed elevated sympathetic nervous system activity.
Psychophysiological and psychometric data suggest a shared prevalence of right-hemispheric dominance in both AD and Pso patient groups. However, the findings indicate distinct psychodermatological mechanisms in AD and Pso.
大脑的每个半球在认知和行为过程中都发挥着特定作用，这被称为半球偏侧化。在慢性皮肤病中，如斑块状银屑病（Pso）和特应性皮炎（AD），额叶半球之间的偏侧化程度可能有助于深入了解皮肤病与心理之间的特定联系。本研究旨在分析Pso和AD患者的半球偏侧化、神经植物性反应和心理测量特征。
该研究纳入了46例Pso患者、56例AD患者和29名健康对照（Ctrl）受试者。参与者接受了额叶脑电图（EEG）测量、心率变异性（HRV）评估和心理测试。使用方差分析进行统计分析，并应用Bonferroni校正进行多重比较。
本研究表明，与Ctrl相比，AD患者（<0.001）和Pso患者（=0.045）均存在显著的右侧前额叶活动偏侧化，AD组和Pso组之间无显著差异（=0.633）。右侧半球优势前额叶激活的AD患者表现出抑制和回避指标增加，而Pso患者表现出交感神经系统活动增强。
心理生理学和心理测量数据表明，AD和Pso患者组中右侧半球优势的发生率较高。然而，研究结果表明AD和Pso存在不同的心理皮肤病学机制。
