Clinic for Dermatovenerology, Clinical Center of Montenegro, 81000 Podgorica, Montenegro.
Faculty of Medicine, University of Montenegro, 81000 Podgorica, Montenegro.
Medicina (Kaunas). 2023 Sep 8;59(9):1622. doi: 10.3390/medicina59091622.
: There are no studies regarding comparative analysis of hematological parameters in patients with psoriasis (PsO) and atopic dermatitis (AD), whereas studies examining serum biomarkers of immunity and inflammation in these entities are scarce and contradictory. We aimed to compare such parameters in patients with PsO and AD. : Patients with PsO ( = 40) and AD ( = 40) were consecutively included in this cross-sectional study. Hematological parameters and biomarkers of immunity and inflammation (interferon-gamma (IFN-γ), interleukine (IL)-22 and C-reactive protein (CRP)) were determined. : While the mean corpuscular volume (MCV) was higher in the PsO group vs. the AD group ( < 0.05), there was no difference in the other examined parameters between groups. A higher neutrophil-to-lymphocyte ratio (NLR) was found in patients with AD > 50 years vs. patients with PsO of similar age ( < 0.05). Higher IL-22 levels were found in patients with AD < 50 years vs. patients with PsO of similar age ( < 0.05). Lower IL-22 levels were found in patients with AD > 50 years vs. patients with AD < 50 years ( < 0.05). Patients with PsO and with comorbidities had lower platelets (PLT), plateletcrit (PCT) and platelet-to-lymphocyte ratio (PLR), whereas lymphocytes, red cell distribution width-to-PLT ratio (RPR) and mean platelet volume/PLT ratio (MPR) were higher vs. PsO patients without comorbidities. Patients with AD and with comorbidities had lower PCT and PLR, whereas RPR was higher vs. AD patients without comorbidities. : A higher pro-inflammatory state (i.e., higher NLR and IL-22) was found in AD vs. PsO in age-specific groups. A higher pro-inflammatory state (i.e., as reflected by platelet indexes) was found in both diseases with comorbidities.
: 目前尚无关于银屑病（PsO）和特应性皮炎（AD）患者血液学参数比较分析的研究，而关于这些疾病的免疫和炎症血清生物标志物的研究则很少且存在矛盾。我们旨在比较 PsO 和 AD 患者的这些参数。 : 本横断面研究连续纳入了 40 例 PsO 患者和 40 例 AD 患者。测定了血液学参数以及免疫和炎症的生物标志物（干扰素-γ（IFN-γ）、白细胞介素（IL）-22 和 C 反应蛋白（CRP））。 : 与 AD 组相比，PsO 组的平均红细胞体积（MCV）更高（<0.05），但两组间其他检查参数无差异。50 岁以上 AD 患者的中性粒细胞与淋巴细胞比值（NLR）高于同龄 PsO 患者（<0.05）。50 岁以下 AD 患者的 IL-22 水平高于同龄 PsO 患者（<0.05）。50 岁以上 AD 患者的 IL-22 水平低于 50 岁以下 AD 患者（<0.05）。合并症的 PsO 患者的血小板（PLT）、血小板压积（PCT）和血小板与淋巴细胞比值（PLR）较低，而淋巴细胞、红细胞分布宽度与 PLT 比值（RPR）和平均血小板体积/PLT 比值（MPR）则较高。合并症的 AD 患者的 PCT 和 PLR 较低，而 RPR 则较高。 : 在特定年龄组中，AD 患者的促炎状态（即更高的 NLR 和 IL-22）高于 PsO 患者。两种疾病合并症患者的促炎状态（如血小板指标所示）更高。
