Tanan Karaca Gamze, Duygu Gonca, Er Nilay, Ozgun Eray
Private Dental Clinic, Canakkale 17110, Türkiye.
Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Tekirdag Namik Kemal University, Tekirdag 59030, Türkiye.
J Clin Med. 2023 Jun 25;12(13):4250. doi: 10.3390/jcm12134250.
This study evaluated the anti-inflammatory effect of platelet-rich fibrin (PRF) applied to the extraction socket after impacted mandibular third molar surgery with subjective and objective parameters. Forty-eight patients with impacted wisdom teeth in bilateral and similar positions were included in the study. The control group was formed with the standard surgery and the PRF group was formed with local PRF application in addition to standard procedure ( = 96). The anti-inflammatory activity of PRF on postoperative 2nd and 7th days was evaluated subjectively by clinical parameters and objectively by biochemical parameters. Postoperative 2nd- and 7th-day follow-up data of pain, edema, and trismus in the PRF group were found to be statistically significantly lower. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were found to be statistically significantly lower in the PRF group than the control in the postoperative 2nd-day follow-up period ( < 0.001). There was no statistically significant difference in interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) parameters when the PRF group and the control group were compared in both follow-up periods ( > 0.05). The study has demonstrated the effectiveness of locally applied PRF after ITM surgery via clinical parameters and objective data. The quantitative analysis of CRP and ERS can be an effective parameter in determining the amount of inflammation after ITM surgery.
本研究通过主观和客观参数评估了富含血小板纤维蛋白（PRF）应用于下颌阻生第三磨牙拔除术后拔牙窝的抗炎效果。48例双侧位置相似的阻生智齿患者纳入本研究。对照组采用标准手术，PRF组在标准手术基础上局部应用PRF（每组 = 96）。通过临床参数主观评估PRF在术后第2天和第7天的抗炎活性，并通过生化参数进行客观评估。发现PRF组术后第2天和第7天疼痛、水肿和张口受限的随访数据在统计学上显著更低。在术后第2天随访期，PRF组的红细胞沉降率（ESR）和C反应蛋白（CRP）在统计学上显著低于对照组（ < 0.001）。在两个随访期比较PRF组和对照组时，白细胞介素6（IL-6）和肿瘤坏死因子-α（TNF-α）参数无统计学显著差异（ > 0.05）。本研究通过临床参数和客观数据证明了ITM手术后局部应用PRF的有效性。CRP和ERS的定量分析可以作为确定ITM手术后炎症程度的有效参数。
