单磷酰脂质A对宿主抵抗细菌感染的影响。
Effect of monophosphoryl lipid A on host resistance to bacterial infection.
作者信息
Chase J J, Kubey W, Dulek M H, Holmes C J, Salit M G, Pearson F C, Ribi E
出版信息
Infect Immun. 1986 Sep;53(3):711-2. doi: 10.1128/iai.53.3.711-712.1986.
Abstract
The ability of monophosphoryl lipid A (MPLA) to enhance nonspecific host resistance to bacterial infections was studied. Mice were treated with MPLA prior to intraperitoneal challenge with Escherichia coli or Staphylococcus epidermidis. Animals received additional MPLA for 2 days postinfection, and survival rates were determined. Ten micrograms of MPLA per mouse significantly improved the survival of animals infected with either bacterial species. Dose-response studies showed significant MPLA-induced protection at doses of 6 micrograms/kg against E. coli challenge and 60 micrograms/kg against S. epidermidis challenge.
摘要
研究了单磷酰脂质A（MPLA）增强宿主对细菌感染的非特异性抵抗力的能力。在用大肠杆菌或表皮葡萄球菌进行腹腔攻击之前，用MPLA处理小鼠。动物在感染后2天接受额外的MPLA，并测定存活率。每只小鼠10微克的MPLA显著提高了感染任一细菌物种的动物的存活率。剂量反应研究表明，6微克/千克的MPLA剂量对大肠杆菌攻击有显著的保护作用，60微克/千克的剂量对表皮葡萄球菌攻击有显著的保护作用。
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