Department of Anaesthesiology and Intensive Care, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Department of Cardiac Anaesthesia and Intensive Therapy, Silesian Center for Heart Diseases, Medical University of Silesia, 41-808 Zabrze, Poland.
Int J Mol Sci. 2023 Jun 28;24(13):10772. doi: 10.3390/ijms241310772.
Despite efforts to improve treatment outcomes, mortality in septic shock remains high. In some patients, despite the use of several adrenergic drugs, features of refractory vasoplegic shock with progressive multiorgan failure are observed. We present a case report of the successful reversal of vasoplegic shock following the use of methylene blue, a selective inhibitor of the inducible form of nitric oxide synthase, which prevents vasodilation in response to inflammatory cytokines. We also briefly review the literature.
尽管人们努力改善治疗结果，但脓毒性休克的死亡率仍然很高。在一些患者中，尽管使用了几种肾上腺素能药物，但仍观察到难治性血管扩张性休克伴有进行性多器官衰竭的特征。我们报告了一例使用亚甲蓝成功逆转血管扩张性休克的病例，亚甲蓝是诱导型一氧化氮合酶的选择性抑制剂，可防止血管对炎症细胞因子的扩张反应。我们还简要回顾了文献。
