Doctoral School, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania.
Department of Physiology, School of Medicine, Istanbul Medipol University, Istanbul 34214, Turkey.
Int J Mol Sci. 2023 Jun 28;24(13):10802. doi: 10.3390/ijms241310802.
Ischemic stroke, a significant neurovascular disorder, currently lacks effective restorative medication. However, recently developed nanomedicines bring renewed promise for alleviating ischemia's effects and facilitating the healing of neurological and physical functions. The aim of this systematic review was to evaluate the efficacy of nanotherapies in animal models of stroke and their potential impact on future stroke therapies. We also assessed the scientific quality of current research focused on nanoparticle-based treatments for ischemic stroke in animal models. We summarized the effectiveness of nanotherapies in these models, considering multiple factors such as their anti-inflammatory, antioxidant, and angiogenetic properties, as well as their safety and biodistribution. We conclude that the application of nanomedicines may reduce infarct size and improve neurological function post-stroke without causing significant organ toxicity.
缺血性脑卒中是一种严重的血管神经疾病，目前缺乏有效的治疗药物。然而，最近开发的纳米药物为减轻缺血影响和促进神经及身体功能恢复带来了新的希望。本系统评价旨在评估纳米疗法在脑卒中动物模型中的疗效及其对未来脑卒中治疗的潜在影响。我们还评估了目前针对缺血性脑卒中动物模型中基于纳米颗粒的治疗方法的研究的科学质量。我们总结了这些模型中纳米疗法的有效性，考虑了多种因素，如抗炎、抗氧化和血管生成特性，以及它们的安全性和生物分布。我们得出结论，纳米药物的应用可能会减少脑卒中后的梗死面积并改善神经功能，而不会引起明显的器官毒性。
