Toivonen L K, Leinonen H
Int J Cardiol. 1986 Aug;12(2):260-2. doi: 10.1016/0167-5273(86)90250-0.
A patient with thioridazine-induced torsades de pointes ventricular tachycardia treated with magnesium sulphate is presented. Due to incessant recurrence of tachycardias it was possible to observe the time course of the effect of 1 g intravenous doses. Suppression of torsades de pointes lasted at best for no more than 18 min and a maintenance infusion was not effective without overdrive pacing. Magnesium sulphate may have value as first aid therapy for drug-induced torsades de pointes ventricular tachycardia. However, its effect disappears rapidly, and, therefore, should not alone be relied on as prophylactic treatment.
本文介绍了一名硫利达嗪诱发尖端扭转型室性心动过速的患者，其接受了硫酸镁治疗。由于心动过速不断复发，得以观察1克静脉注射剂量的效果的时间进程。尖端扭转型室速的抑制效果最多持续不超过18分钟，且在没有超速起搏的情况下维持输注无效。硫酸镁可能对药物诱发的尖端扭转型室性心动过速有急救治疗价值。然而，其效果迅速消失，因此，不应单独依赖其作为预防性治疗。
