Division of Nephrology, Department of Medicine, Penn State University College of Medicine, Hershey, PA 17033, USA.
Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA 17033, USA.
Int J Mol Sci. 2023 Jul 4;24(13):11067. doi: 10.3390/ijms241311067.
Macrophage infiltration and accumulation is a hallmark of chronic kidney disease. Tissue plasminogen activator (tPA) is a serine protease regulating the homeostasis of blood coagulation, fibrinolysis, and matrix degradation, and has been shown to act as a cytokine to trigger various receptor-mediated intracellular signal pathways, modulating macrophage function in response to kidney injury. In this review, we discuss the current understanding of tPA-modulated macrophage function and underlying signaling mechanisms during kidney fibrosis and inflammation.
巨噬细胞浸润和积聚是慢性肾脏病的一个标志。组织型纤溶酶原激活物（tPA）是一种丝氨酸蛋白酶，调节血液凝固、纤维蛋白溶解和基质降解的动态平衡，已被证明作为细胞因子发挥作用，触发各种受体介导的细胞内信号通路，调节巨噬细胞功能以应对肾脏损伤。在这篇综述中，我们讨论了目前对 tPA 调节的巨噬细胞功能及其在肾脏纤维化和炎症过程中的潜在信号机制的理解。
