流感疫苗接种后的安替比林动力学
Antipyrine kinetics following influenza vaccination.
作者信息
Simonet R, Descotes J, Evreux J C
出版信息
Int J Clin Pharmacol Res. 1986;6(3):231-3.
PMID:3744625
Abstract
To test the hypothesis that hepatic drug metabolism affected the pharmacokinetics of antipyrine, 12 persons who had received vaccination against influenza were given antipyrine on the fourth day following. Plasma antipyrine was assayed from venous blood samples taken 5, 11 and 24 h later. The results indicate that the immunization procedure transiently increased the hepatic drug metabolizing enzyme activity against antipyrine.
摘要
为验证肝药物代谢影响安替比林药代动力学这一假说，对12名接种流感疫苗的人员在接种后第四天给予安替比林。于给药后5小时、11小时和24小时采集静脉血样，测定血浆中的安替比林。结果表明，免疫程序使肝脏针对安替比林的药物代谢酶活性暂时升高。
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