流感疫苗接种后茶碱清除率降低。
Decreased elimination of theophylline after influenza vaccination.
作者信息
Renton K W, Gray J D, Hall R I
出版信息
Can Med Assoc J. 1980 Aug 23;123(4):288-90.
Abstract
The elimination of theophylline is decreased after vaccination against influenza. In three patients receiving 200 mg of oxtriphylline (equivalent to 128 mg of theophylline) every 6 hours by mouth the serum theophylline levels rose after vaccination, and in four healthy volunteers given the same dose of oxtriphylline 24 hours after vaccination the half-life of theophylline increased by an average of 122%. Two of the three patients showed signs of a toxic reaction to the drug. These results suggest that the elimination of theophylline is impaired to a clinically important degree after influenza vaccination and that the resulting levels of the drug can be toxic even when conventional therapeutic doses of theophylline are given.
摘要
接种流感疫苗后，茶碱的清除率降低。三名患者每6小时口服200毫克多索茶碱（相当于128毫克茶碱），接种疫苗后血清茶碱水平升高；四名健康志愿者在接种疫苗24小时后给予相同剂量的多索茶碱，茶碱的半衰期平均增加了122%。三名患者中有两名出现了药物中毒反应迹象。这些结果表明，接种流感疫苗后茶碱的清除受到临床上重要程度的损害，即使给予常规治疗剂量的茶碱，所产生的药物水平也可能有毒。
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