Scientific Club of Specialized Biological Analyzes, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry and Laboratory Hematology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Int J Mol Sci. 2023 Jul 7;24(13):11206. doi: 10.3390/ijms241311206.
Lung cancer is one of the most common cancers in the population and is characterized by non-specific symptoms that delay the diagnosis and reduce the effectiveness of oncological treatment. Due to the difficult placement of the tumor, one of the main methods of lung cancer treatment is radiotherapy, which damages the DNA of cancer cells, inducing their apoptosis. However, resistance to ionizing radiation may develop during radiotherapy cycles, leading to an increase in the number of DNA points of control that protect cells from apoptosis. Cancer stem cells are essential for radioresistance, and due to their ability to undergo epithelial-mesenchymal transition, they modify the phenotype, bypassing the genotoxic effect of radiotherapy. It is therefore necessary to search for new methods that could improve the cytotoxic effect of cells through new mechanisms of action. Chinese medicine, with several thousand years of tradition, offers a wide range of possibilities in the search for compounds that could be used in conventional medicine. This review introduces the potential candidates that may present a radiosensitizing effect on lung cancer cells, breaking their radioresistance. Additionally, it includes candidates taken from conventional medicine-drugs commonly available in pharmacies, which may also be significant candidates.
肺癌是人群中最常见的癌症之一，其特征是非特异性症状，这些症状会延迟诊断并降低肿瘤治疗的效果。由于肿瘤位置难以确定，肺癌的主要治疗方法之一是放疗，放疗会破坏癌细胞的 DNA，诱导其凋亡。然而，在放疗周期中可能会产生对电离辐射的抵抗力，导致保护细胞免受凋亡的 DNA 控制点数量增加。癌症干细胞是放射抗性的关键，并且由于它们能够进行上皮-间充质转化，它们会改变表型，绕过放疗的遗传毒性作用。因此，有必要寻找新的方法，通过新的作用机制来提高细胞的细胞毒性作用。具有几千年传统的中医药为寻找可用于常规医学的化合物提供了广泛的可能性。这篇综述介绍了可能对肺癌细胞具有放射增敏作用的潜在候选物，从而打破其放射抗性。此外，还包括来自常规医学的候选物-药房中常见的药物，它们也可能是重要的候选物。
