Department of Chemistry, Faculty of Science, King Abdul-Aziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Department of Chemistry, Faculty of Science, University of Allahabad (AoU), Prayagraj 211002, Uttar Pradesh, India.
Molecules. 2023 Jun 25;28(13):4992. doi: 10.3390/molecules28134992.
For the creation of adaptable carbonyl compounds in organic synthesis, the oxidation of alcohols is a crucial step. As a sustainable alternative to the harmful traditional oxidation processes, transition-metal catalysts have recently attracted a lot of interest in acceptorless dehydrogenation reactions of alcohols. Here, using well-defined, air-stable palladium(II)-NHC catalysts (A-F), we demonstrate an effective method for the catalytic acceptorless dehydrogenation (CAD) reaction of secondary benzylic alcohols to produce the corresponding ketones and molecular hydrogen (H). Catalytic acceptorless dehydrogenation (CAD) has been successfully used to convert a variety of alcohols, including electron-rich/electron-poor aromatic secondary alcohols, heteroaromatic secondary alcohols, and aliphatic cyclic alcohols, into their corresponding value-added ketones while only releasing molecular hydrogen as a byproduct.
在有机合成中创造适应性羰基化合物时，醇的氧化是一个关键步骤。作为对传统有害氧化过程的可持续替代方案，过渡金属催化剂最近在醇的无受体脱氢反应中引起了广泛关注。在这里，我们使用定义明确、空气稳定的钯 (II)-NHC 催化剂 (A-F)，展示了一种有效方法，可用于催化无受体脱氢 (CAD) 反应，将仲苄醇转化为相应的酮和氢气 (H)。催化无受体脱氢 (CAD) 已成功用于将各种醇（包括富电子/缺电子芳香族仲醇、杂芳族仲醇和脂环醇）转化为相应的有价值的酮，而仅释放氢气作为副产物。
