Shandong Key Laboratory of Molecular Engineering, State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Shandong Provincial Technology Center of Jining Zhongyin Electrochemical Co., Ltd., Jining 272500, China.
Molecules. 2023 Jul 4;28(13):5211. doi: 10.3390/molecules28135211.
Bio-based packaging materials and efficient drug delivery systems have garnered attention in recent years. Among the soluble cellulose derivatives, carboxymethyl cellulose (CMC) stands out as a promising candidate due to its biocompatibility, biodegradability, and wide resources. However, CMC-based films have limited mechanical properties, which hinders their widespread application. This paper aims to address this issue by exploring the molecular interactions between CMC and various additives with different molecular structures, using the rheological method. The additives include O-carboxymethylated chitosan (O-CMCh), N-2-hydroxypropyl-3-trimethylammonium-O-carboxymethyl chitosan (HTCMCh), hydroxypropyltrimethyl ammonium chloride chitosan (HACC), cellulose nanocrystals (CNC), and cellulose nanofibers (CNF). By investigating the rheological properties of film-forming solutions, we aimed to elucidate the influencing mechanisms of the additives on CMC-based films at the molecular level. Various factors affecting rheological properties, such as molecular structure, additive concentration, and temperature, were examined. The results revealed that the interactions between CMC and the additives were dependent on the charge of the additives. Electrostatic interactions were observed for HACC and HTCMCh, while O-CMCh, CNC, and CNF primarily interacted through hydrogen bonds. Based on these rheological properties, several systems were selected to prepare the films, which exhibited excellent transparency, wettability, mechanical properties, biodegradability, and absence of cytotoxicity. The desirable characteristics of these selected films demonstrated the strong biocompatibility between CMC and chitosan and cellulose derivatives. This study offers insights into the preparation of CMC-based food packaging materials with specific properties.
近年来，生物基包装材料和高效药物输送系统受到了关注。在可溶性纤维素衍生物中，羧甲基纤维素（CMC）由于其生物相容性、可生物降解性和广泛的资源而成为一种很有前途的候选材料。然而，CMC 基薄膜的机械性能有限，这限制了其广泛应用。本文旨在通过流变学方法研究 CMC 与具有不同分子结构的各种添加剂之间的分子相互作用，解决这一问题。添加剂包括 O-羧甲基壳聚糖（O-CMCh）、N-2-羟丙基-3-三甲基氯化铵-O-羧甲基壳聚糖（HTCMCh）、羟丙基三甲基氯化铵壳聚糖（HACC）、纤维素纳米晶体（CNC）和纤维素纳米纤维（CNF）。通过研究成膜溶液的流变性能，我们旨在从分子水平阐明添加剂对 CMC 基薄膜的影响机制。研究了影响流变性能的各种因素，如分子结构、添加剂浓度和温度。结果表明，CMC 与添加剂之间的相互作用取决于添加剂的电荷。HACC 和 HTCMCh 存在静电相互作用，而 O-CMCh、CNC 和 CNF 主要通过氢键相互作用。基于这些流变性能，选择了几个体系来制备薄膜，这些薄膜表现出优异的透明度、润湿性、机械性能、生物降解性和无细胞毒性。这些选定薄膜的理想特性表明 CMC 与壳聚糖和纤维素衍生物之间具有很强的生物相容性。本研究为制备具有特定性能的 CMC 基食品包装材料提供了思路。
