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一种从树枝中提取的正己烷提取物及其主要化合物甲基脱氢丁香酚 B 对小鼠海绵体诱导性炎症的体内评估。

An In Vivo Assessment of the Effect of Hexane Extract from Branches and Its Main Compound, Methyldehydrodieugenol B, on Murine Sponge-Induced Inflammation.

机构信息

Department of Physiological Sciences, Federal University of Uberlandia, Uberlandia 38408-100, Brazil.

Center for Natural and Human Sciences, Federal University of ABC, Santo Andre 09210-180, Brazil.

出版信息

Molecules. 2023 Jul 6;28(13):5247. doi: 10.3390/molecules28135247.

DOI:10.3390/molecules28135247
PMID:37446907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10343220/
Abstract

The present study aims to explore the anti-inflammatory potential activity of the hexane extract from branches (HEB) of (Lauraceae) and its main compound, methyldehydrodieugenol B, in the inflammatory response induced by a murine implant sponge model. HPLC-ESI/MS analysis of HEB led to the identification of six chemically related neolignans, with methyldehydrodieugenol B as the main compound. An in silico analysis of the pharmacokinetic parameters of the identified compounds suggested moderate solubility but good absorption and biodistribution in vivo. Thus, the treatment of mice with HEB using in vivo assays indicated that HEB promoted pro-inflammatory, antiangiogenic, and antifibrogenic effects, whereas treatment with methyldehydrodieugenol B caused anti-inflammatory, antifibrogenic, and antiangiogenic effects. The obtained results shown the therapeutic potential of HEB and methyldehydrodieugenol B in the treatment of pathologies associated with inflammation and angiogenesis, including chronic wounds.

摘要

本研究旨在探讨樟科（Lauraceae）树枝正己烷提取物（HEB）及其主要化合物甲基脱氢丁香酚 B 对小鼠植入海绵模型诱导的炎症反应的抗炎潜力活性。通过高效液相色谱-电喷雾/质谱（HPLC-ESI/MS）分析，鉴定出六种化学相关的新木脂素，其中甲基脱氢丁香酚 B 为主要化合物。对鉴定出的化合物的药代动力学参数进行的计算机分析表明，它们具有中等的溶解度，但在体内具有良好的吸收和分布。因此，通过体内试验用 HEB 治疗小鼠表明，HEB 促进了促炎、抗血管生成和抗纤维化作用，而用甲基脱氢丁香酚 B 治疗则引起了抗炎、抗纤维化和抗血管生成作用。研究结果表明，HEB 和甲基脱氢丁香酚 B 具有治疗与炎症和血管生成相关的病理的潜力，包括慢性伤口。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/2cf2dbed96c7/molecules-28-05247-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/2d0d369aa2e4/molecules-28-05247-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/49edabf763a2/molecules-28-05247-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/85e88c6b68c3/molecules-28-05247-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/cec8929a1be6/molecules-28-05247-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/630718e5692b/molecules-28-05247-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/9b19f0667fed/molecules-28-05247-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/a6b203ec3f35/molecules-28-05247-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/2cf2dbed96c7/molecules-28-05247-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/2d0d369aa2e4/molecules-28-05247-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/49edabf763a2/molecules-28-05247-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/85e88c6b68c3/molecules-28-05247-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/cec8929a1be6/molecules-28-05247-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/630718e5692b/molecules-28-05247-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/9b19f0667fed/molecules-28-05247-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/a6b203ec3f35/molecules-28-05247-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b33/10343220/2cf2dbed96c7/molecules-28-05247-g008.jpg

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