Department of Molecular Biotechnology and Genetics, University of Lodz, Banacha Street 12/16, 90-237 Lodz, Poland.
Doctoral School of Exact and Natural Sciences, University of Lodz, Banacha Street 12/16, 90-237 Lodz, Poland.
Molecules. 2023 Jul 6;28(13):5246. doi: 10.3390/molecules28135246.
Cellular signaling pathways involved in the maintenance of the equilibrium between cell proliferation and apoptosis have emerged as rational targets that can be exploited in the prevention and treatment of cancer. Epigallocatechin-3-gallate (EGCG) is the most abundant phenolic compound found in green tea. It has been shown to regulate multiple crucial cellular signaling pathways, including those mediated by EGFR, JAK-STAT, MAPKs, NF-κB, PI3K-AKT-mTOR, and others. Deregulation of the abovementioned pathways is involved in the pathophysiology of cancer. It has been demonstrated that EGCG may exert anti-proliferative, anti-inflammatory, and apoptosis-inducing effects or induce epigenetic changes. Furthermore, preclinical and clinical studies suggest that EGCG may be used in the treatment of numerous disorders, including cancer. This review aims to summarize the existing knowledge regarding the biological properties of EGCG, especially in the context of cancer treatment and prophylaxis.
细胞信号通路在维持细胞增殖和凋亡之间的平衡中起着重要作用，它们已成为癌症预防和治疗的合理靶点。表没食子儿茶素没食子酸酯（EGCG）是绿茶中含量最丰富的酚类化合物。它被证明可以调节多种关键的细胞信号通路，包括 EGFR、JAK-STAT、MAPKs、NF-κB、PI3K-AKT-mTOR 等介导的信号通路。上述通路的失调与癌症的病理生理学有关。已经证明 EGCG 可能具有抗增殖、抗炎和诱导细胞凋亡的作用，或诱导表观遗传改变。此外，临床前和临床研究表明，EGCG 可用于治疗多种疾病，包括癌症。本综述旨在总结 EGCG 的生物学特性的现有知识，特别是在癌症治疗和预防方面。
