Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China.
Nutrients. 2023 Jun 21;15(13):2833. doi: 10.3390/nu15132833.
Chlorogenic acid (CGA) is a powerful antioxidant polyphenol molecule found in many diets and liquid beverages, playing a preventive and therapeutic role in various diseases caused by oxidative stress and inflammation. Recent research has found that CGA can not only improve clinical symptoms in PCOS patients but also improve follicular development, hormone status, and oxidative stress in PCOS rats, indicating the therapeutic effect of CGA on PCOS. Notably, our previous series of studies has demonstrated the expression changes and regulatory mechanisms of HIF-1alpha signaling in PCOS ovaries. Considering the regulatory effect of CGA on the HIF-1alpha pathway, the present article systematically elucidates the therapeutic role and molecular mechanisms of HIF-1alpha signaling during the treatment of PCOS by CGA, including follicular development, steroid synthesis, inflammatory response, oxidative stress, and insulin resistance, in order to further understand the mechanisms of CGA effects in different types of diseases and to provide a theoretical basis for further promoting CGA-rich diets and beverages simultaneously.
绿原酸（CGA）是一种存在于许多饮食和液体饮料中的强效抗氧化多酚分子，在由氧化应激和炎症引起的各种疾病中发挥预防和治疗作用。最近的研究发现，CGA 不仅可以改善 PCOS 患者的临床症状，还可以改善 PCOS 大鼠的卵泡发育、激素状态和氧化应激，表明 CGA 对 PCOS 具有治疗作用。值得注意的是，我们之前的一系列研究已经证明了 HIF-1alpha 信号在 PCOS 卵巢中的表达变化和调节机制。鉴于 CGA 对 HIF-1alpha 通路的调节作用，本文系统阐明了 CGA 治疗 PCOS 过程中 HIF-1alpha 信号的治疗作用和分子机制，包括卵泡发育、类固醇合成、炎症反应、氧化应激和胰岛素抵抗，以便进一步了解 CGA 在不同类型疾病中的作用机制，并为进一步促进富含 CGA 的饮食和饮料提供理论依据。
