Unit of Primary Health Care, Department of General Practice and Primary Health Care, Faculty of Medicine, Helsinki University Central Hospital, University of Helsinki, 00014 Helsinki, Finland.
Department of Food and Nutrition, University of Helsinki, 00014 Helsinki, Finland.
Nutrients. 2023 Jun 27;15(13):2922. doi: 10.3390/nu15132922.
Sarcopenia is common in people 70+ years of age, and its prevalence increases with further aging. Insufficient energy and protein intake accelerates muscle loss, whereas sufficient protein intake and milk fat globule membrane (MFGM) may suppress age-associated deterioration of muscle mass and strength. Our objective was to test whether a snack product high in MFGM and protein would improve physical performance in older women.
In this 12-week randomized controlled trial, women ≥ 70 years, with protein intake < 1.2 g/body weight (BW) kg/day (d), were randomized into intervention (n = 51) and control (n = 50) groups. The intervention group received a daily snack product containing ≥ 23 g of milk protein and 3.6-3.9 g of MFGM. Both groups were advised to perform a five-movement exercise routine. The primary outcome was the change in the five-time-sit-to-stand test between the groups. Secondary outcomes included changes in physical performance, cognition, hand grip strength, and health-related quality of life.
The change in the five-time-sit-to-stand test did not differ between the intervention and the control groups. The change in the total Short Physical Performance Battery score differed significantly, favoring the intervention group ( = 0.020), and the balance test showed the largest difference. Protein intake increased significantly in the intervention group (+14 g) compared to the control group (+2 g). No other significant changes were observed.
Our results indicate that the combination of MFGM and protein may improve the physical performance-related balance of older women.
肌少症在 70 岁以上人群中很常见，且其发病率随着年龄的进一步增长而增加。能量和蛋白质摄入不足会加速肌肉流失，而充足的蛋白质摄入和乳脂肪球膜（MFGM）可能会抑制与年龄相关的肌肉质量和力量下降。我们的目的是检验富含 MFGM 和蛋白质的零食产品是否会改善老年女性的身体机能。
在这项为期 12 周的随机对照试验中，年龄≥70 岁且蛋白质摄入量<1.2 g/体重（BW）kg/天（d）的女性被随机分为干预组（n=51）和对照组（n=50）。干预组每天食用含有≥23 g牛奶蛋白和 3.6-3.9 g MFGM 的零食。两组均被建议进行五项运动常规训练。主要结局指标是两组间五次坐站测试的变化。次要结局指标包括身体机能、认知、手握力和健康相关生活质量的变化。
五次坐站测试的变化在干预组和对照组之间没有差异。总短体适能电池评分的变化差异显著，干预组更优（=0.020），平衡测试的差异最大。干预组的蛋白质摄入量显著增加（+14 g），而对照组仅增加了（+2 g）。未观察到其他显著变化。
我们的结果表明，MFGM 和蛋白质的结合可能会改善老年女性与身体机能相关的平衡。
