State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China.
Nutrients. 2023 Jun 28;15(13):2934. doi: 10.3390/nu15132934.
Lifestyle has been linked to the incidence of heart failure, but the underlying biological mechanisms remain unclear. Using the metabolomic, lifestyle, and heart failure data of the UK Biobank, we identified and validated healthy lifestyle-related metabolites in a matched case-control and cohort study, respectively. We then evaluated the association of healthy lifestyle-related metabolites with heart failure (HF) risk and the added predictivity of these healthy lifestyle-associated metabolites for HF. Of 161 metabolites, 8 were identified to be significantly related to healthy lifestyle. Notably, omega-3 fatty acids and docosahexaenoic acid (DHA) positively associated with a healthy lifestyle score (HLS) and exhibited a negative association with heart failure risk. Conversely, creatinine negatively associated with a HLS, but was positively correlated with the risk of HF. Adding these three metabolites to the classical risk factor prediction model, the prediction accuracy of heart failure incidence can be improved as assessed by the C-statistic (increasing from 0.806 [95% CI, 0.796-0.816] to 0.844 [95% CI, 0.834-0.854], -value < 0.001). A healthy lifestyle is associated with significant metabolic alterations, among which metabolites related to healthy lifestyle may be critical for the relationship between healthy lifestyle and HF. Healthy lifestyle-related metabolites might enhance HF prediction, but additional validation studies are necessary.
生活方式与心力衰竭的发生率有关，但潜在的生物学机制尚不清楚。本研究使用 UK Biobank 的代谢组学、生活方式和心力衰竭数据，分别在匹配的病例对照和队列研究中确定和验证了与健康生活方式相关的代谢物。然后，我们评估了与健康生活方式相关的代谢物与心力衰竭（HF）风险的相关性，以及这些与健康生活方式相关的代谢物对 HF 的预测能力。在 161 种代谢物中，有 8 种与健康生活方式显著相关。值得注意的是，ω-3 脂肪酸和二十二碳六烯酸（DHA）与健康生活方式评分（HLS）呈正相关，与心力衰竭风险呈负相关。相反，肌酐与 HLS 呈负相关，但与 HF 风险呈正相关。将这三种代谢物添加到经典的风险因素预测模型中，可以通过 C 统计量（从 0.806[95%CI，0.796-0.816]增加到 0.844[95%CI，0.834-0.854]，-值<0.001）来评估心力衰竭发生率的预测准确性。健康的生活方式与显著的代谢改变有关，其中与健康生活方式相关的代谢物可能是健康生活方式与 HF 之间关系的关键。与健康生活方式相关的代谢物可能增强 HF 预测，但需要进一步的验证研究。
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