Department of Psychology, University of Almeria, 04120 Almeria, Spain.
Health Research Center, University of Almeria, 04120 Almeria, Spain.
Nutrients. 2023 Jun 30;15(13):2993. doi: 10.3390/nu15132993.
Alcohol use poses a significant global health concern, leading to serious physical and socioeconomic issues worldwide. The current treatment options for problematic alcohol consumption are limited, leading to the exploration of alternative approaches, such as nutraceuticals. One promising target is very-long-chain -3 polyunsaturated fatty acids (VLC -3 PUFAs). This review aims to compile the most relevant pre-clinical and clinical evidence on the effect of VLC -3 PUFAs on alcohol use disorders and related outcomes. The findings suggest that VLC -3 PUFAs may alleviate the physiological changes induced by alcohol consumption, including neuroinflammation and neurotransmitter dysregulation. Additionally, they can reduce withdrawal symptoms, improve mood, and reduce stress level, all of which are closely associated with problematic alcohol consumption. However, more research is required to fully understand the precise mechanisms by which VLC -3 PUFAs exert their function. Furthermore, PUFAs should not be considered a standalone solution, but as a complement to other therapeutic approaches. Although preliminary evidence supports the potential therapeutic effect of VLC -3 PUFAs on problematic alcohol consumption, additional research is needed to validate these findings and determine the optimal use of PUFAs as part of a comprehensive approach to the treatment of alcohol use disorders.
饮酒是一个重大的全球健康问题，在世界范围内导致严重的身体和社会经济问题。目前针对饮酒问题的治疗选择有限，因此需要探索替代方法，如营养保健品。一种有前途的目标是非常长链 -3 多不饱和脂肪酸 (VLC -3 PUFA)。本综述旨在汇编关于 VLC -3 PUFA 对酒精使用障碍和相关结果影响的最相关的临床前和临床证据。研究结果表明，VLC -3 PUFA 可能减轻酒精消费引起的生理变化，包括神经炎症和神经递质失调。此外，它们可以减少戒断症状，改善情绪，降低压力水平，所有这些都与饮酒问题密切相关。然而，需要进一步的研究来充分了解 VLC -3 PUFA 发挥作用的确切机制。此外，不应将 PUFAs 视为单独的解决方案，而应将其作为其他治疗方法的补充。尽管初步证据支持 VLC -3 PUFA 对饮酒问题的潜在治疗效果，但需要进一步的研究来验证这些发现，并确定 PUFAs 作为治疗酒精使用障碍综合方法的一部分的最佳用途。
