Ghosh Animesh, Kozlowski Konrad, Steele Terry W J
School of Materials Science and Engineering (MSE), Nanyang Technological University (NTU), Singapore 639798, Singapore.
Polymers (Basel). 2023 Jul 1;15(13):2921. doi: 10.3390/polym15132921.
The development of new bioadhesives with integrated properties remains an unmet clinical need to replace staples or sutures. Current bioadhesives do not allow electronic activation, which would allow expansion into laparoscopic and robotic surgeries. To address this deficiency, voltage-activated adhesives have been developed on both carbene- and catechol-based chemical precursors. Herein, a third platform of voltage-activated adhesive is evaluated based on lipoic acid, a non-toxic dithiolane found in aerobic metabolism and capable of ring-opening polymerization. The electro-rheological and adhesive properties of lithium, sodium, and potassium salts of lipoic acid are applied for wet tissue adhesion. At ambient conditions, potassium lipoate displays higher storage modulus than lithium or sodium salt under similar conditions. Voltage stimulation significantly improves gelation kinetics to Na- and K-lipoates, while Li-lipoate is found to not require voltage stimulation for gelation. Lap shear adhesion strength on wetted collagen substrates reveals that the synthetic metal lipoates have comparable adhesion strength to fibrin sealants without viral or ethical risks.
开发具有综合性能的新型生物粘合剂仍然是满足临床需求以替代订书钉或缝线的未竟之事。当前的生物粘合剂不具备电子激活功能，而电子激活功能可使生物粘合剂应用于腹腔镜手术和机器人手术。为解决这一缺陷，基于卡宾和儿茶酚化学前体开发了电压激活粘合剂。在此，基于硫辛酸评估了电压激活粘合剂的第三个平台，硫辛酸是一种存在于有氧代谢中的无毒二硫杂环戊烷，能够进行开环聚合。硫辛酸的锂盐、钠盐和钾盐的电流变和粘合性能被应用于湿组织粘附。在环境条件下，在相似条件下，硫代钾盐的储能模量高于锂盐或钠盐。电压刺激显著改善了硫代钠和硫代钾盐的凝胶化动力学，而发现硫代锂盐凝胶化不需要电压刺激。在湿润胶原底物上的搭接剪切粘附强度表明，合成金属硫代酸盐具有与纤维蛋白密封剂相当的粘附强度，且无病毒或伦理风险。
