Department of Analytical Chemistry, Iuliu Hațieganu University of Medicine and Pharmacy, 8 Victor Babes, 400012 Cluj-Napoca, Romania.
A-Sense Lab, University of Antwerp, Groenenborgerlaan 171, 2010 Antwerp, Belgium.
Sensors (Basel). 2023 Jul 6;23(13):6193. doi: 10.3390/s23136193.
Methamphetamine (MAP) is a highly addictive and illegal stimulant drug that has a significant impact on the central nervous system. Its detection in biological and street samples is crucial for various organizations involved in forensic medicine, anti-drug efforts, and clinical diagnosis. In recent years, nanotechnology and nanomaterials have played a significant role in the development of analytical sensors for MAP detection. In this study, a fast, simple, and cost-effective electrochemical sensor is presented that is used for the sensitive detection of MAP in confiscated street samples with a complex matrix. The optimized screen-printed sensor based on a carbon working electrode modified with graphene demonstrated an excellent limit of detection, good sensitivity, and a wide dynamic range (1-500 μM) for the target illicit drug both for standard solutions and real samples (seized samples, tap water, and wastewater samples). It can detect MAP at concentrations as low as 300 nM in real samples. This limit of detection is suitable for the rapid preliminary screening of suspicious samples in customs, ports, airports, and on the street. Furthermore, the sensor exhibits a good recovery rate, indicating its reliability and repeatability. This quality is crucial for ensuring consistent and accurate results during screening processes.
甲基苯丙胺（MAP）是一种高度成瘾和非法的兴奋剂药物，对中枢神经系统有重大影响。在涉及法医学、禁毒工作和临床诊断的各种组织中，对生物和街头样本中 MAP 的检测至关重要。近年来，纳米技术和纳米材料在开发用于 MAP 检测的分析传感器方面发挥了重要作用。在这项研究中，提出了一种快速、简单和具有成本效益的电化学传感器，用于对具有复杂基质的缴获街头样本中 MAP 进行敏感检测。基于修饰有石墨烯的碳工作电极的优化丝网印刷传感器对目标非法药物（标准溶液和实际样品（缴获样品、自来水和废水样品））具有出色的检测限、良好的灵敏度和宽动态范围（1-500μM）。它可以在实际样品中检测到浓度低至 300nM 的 MAP。这种检测限适用于海关、港口、机场和街头对可疑样本的快速初步筛选。此外，传感器显示出良好的回收率，表明其可靠性和可重复性。在筛选过程中，这种质量对于确保一致和准确的结果至关重要。
