利用肌电信号样本熵评估多发性硬化症中的肌肉疲劳：概念验证
Assessing Muscle Fatigue in Multiple Sclerosis using the Sample Entropy of Electromyographic Signals: A Proof of Concept.
作者信息
Gomez-Hernández Marina, Olaya-Mira Natali, Viloria-Barragán Carolina, Henao-Pérez Julieta, Rojas-Mora Jessica María, Díaz-Londoño Gloria
机构信息
Faculty of Exact and Applied Sciences, Metropolitan Technological Institute, Medellín, Colombia.
Biomedical Research and Innovation Group (GI2B), Faculty of Exact and Applied Sciences, Metropolitan Technological Institute, Medellín, Colombia.
出版信息
J Med Signals Sens. 2023 May 29;13(2):153-159. doi: 10.4103/jmss.jmss_184_21. eCollection 2023 Apr-Jun.
BACKGROUND
Multiple sclerosis (MS) is a progressive and neurodegenerative disease of the central nervous system. Its symptoms vary greatly, which makes its diagnosis complex, expensive, and time-consuming. One of its most prevalent symptoms is muscle fatigue. It occurs in about 92% of patients with MS (PwMS) and is defined as a decrease in maximal strength or energy production in response to contractile activity. This article aims to compare the behavior of a healthy control (HC) with that of a patient with MS before and after muscle fatigue.
METHODS
For this purpose, a static baropodometric test and a dynamic electromyographic analysis are performed to calculate the area of the stabilometric ellipse, the remitting MS (RMS) value, and the sample entropy (SampEn) of the signals, as a proof of concept to explore the feasibility of this test in the muscle fatigue quantitative analysis; in addition, the statistical analysis was realized to verify the results.
RESULTS
According to the results, the ellipse area increased in the presence of muscle fatigue, indicating a decrease in postural stability. Likewise, the RMS value increased in the MS patient and decreased in the HC subject and the opposite behavior in the SampEn was observed in the presence of muscle fatigue.
CONCLUSION
Thus, this study demonstrates that SampEn is a viable parameter to estimate muscle fatigue in PwMS and other neuromuscular diseases.
背景
多发性硬化症（MS）是一种中枢神经系统的进行性神经退行性疾病。其症状差异很大，这使得其诊断复杂、昂贵且耗时。其最常见的症状之一是肌肉疲劳。约92%的多发性硬化症患者（PwMS）会出现肌肉疲劳，它被定义为因收缩活动而导致的最大力量或能量产生的下降。本文旨在比较健康对照（HC）与多发性硬化症患者在肌肉疲劳前后的表现。
方法
为此，进行静态压力足底测试和动态肌电图分析，以计算稳定椭圆面积、缓解型多发性硬化症（RMS）值和信号的样本熵（SampEn），作为探索该测试在肌肉疲劳定量分析中可行性的概念验证；此外，进行统计分析以验证结果。
结果
根据结果，在存在肌肉疲劳时椭圆面积增加，表明姿势稳定性下降。同样，MS患者的RMS值增加，而HC受试者的RMS值下降，并且在存在肌肉疲劳时观察到SampEn的行为相反。
结论
因此，本研究表明SampEn是估计PwMS和其他神经肌肉疾病中肌肉疲劳的可行参数。
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