Yekani Mina, Azargun Robab, Sharifi Simin, Nabizadeh Edris, Nahand Javid Sadri, Ansari Navideh Karimi, Memar Mohammad Yousef, Soki Jozsef'
Department of Microbiology, Faculty of Medicine Kashan University of Medical Sciences Kashan Iran.
Infectious and Tropical Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran.
Health Sci Rep. 2023 Jul 11;6(7):e1418. doi: 10.1002/hsr2.1418. eCollection 2023 Jul.
The discovery and development of antimicrobial drugs were one of the most significant advances in medicine, but the evolution of microbial resistance limited the efficiency of these drugs.
This paper reviews the collateral sensitivity in bacteria and its potential and limitation as a new target for treating infections.
Knowledge mechanisms of resistance to antimicrobial agents are useful to trace a practical approach to treat and control of resistant pathogens. The effect of a resistance mechanism to certain antibiotics on the susceptibility or resistance to other drugs is a key point that may be helpful for applying a strategy to control resistance challenges. In an evolutionary trade-off known as collateral sensitivity, the resistance mechanism to a certain drug may be mediated by the hypersensitivity to other drugs. Collateral sensitivity has been described for different drugs in various bacteria, but the molecular mechanisms affecting susceptibility are not well demonstrated. Collateral sensitivity could be studied to detect its potential in the battle against resistance crisis as well as in the treatment of pathogens adapting to antibiotics. Collateral sensitivity-based antimicrobial therapy may have the potential to limit the emergence of antibiotic resistance.
抗菌药物的发现与研发是医学领域最重大的进展之一，但微生物耐药性的演变限制了这些药物的疗效。
本文综述细菌中的 collateral 敏感性及其作为治疗感染新靶点的潜力与局限性。
了解对抗菌药物的耐药机制有助于探寻治疗和控制耐药病原体的实用方法。一种耐药机制对某些抗生素的作用对其他药物敏感性或耐药性的影响是一个关键点，这可能有助于应用控制耐药挑战的策略。在一种被称为 collateral 敏感性的进化权衡中，对某种药物的耐药机制可能由对其他药物的超敏反应介导。不同细菌中不同药物的 collateral 敏感性已有描述，但影响敏感性的分子机制尚未得到充分证实。可以研究 collateral 敏感性，以检测其在对抗耐药危机以及治疗适应抗生素的病原体方面的潜力。基于 collateral 敏感性的抗菌治疗可能有潜力限制抗生素耐药性的出现。
