Pál Csaba, Papp Balázs, Lázár Viktória
Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary.
Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary.
Trends Microbiol. 2015 Jul;23(7):401-7. doi: 10.1016/j.tim.2015.02.009. Epub 2015 Mar 25.
Understanding how evolution of microbial resistance towards a given antibiotic influences susceptibility to other drugs is a challenge of profound importance. By combining laboratory evolution, genome sequencing, and functional analyses, recent works have charted the map of evolutionary trade-offs between antibiotics and have explored the underlying molecular mechanisms. Strikingly, mutations that caused multidrug resistance in bacteria simultaneously enhanced sensitivity to many other unrelated drugs (collateral sensitivity). Here, we explore how this emerging research sheds new light on resistance mechanisms and the way it could be exploited for the development of alternative antimicrobial strategies.
了解微生物对特定抗生素的耐药性进化如何影响对其他药物的敏感性是一项极其重要的挑战。通过结合实验室进化、基因组测序和功能分析，近期的研究绘制了抗生素之间进化权衡的图谱，并探索了潜在的分子机制。引人注目的是，导致细菌多药耐药的突变同时增强了对许多其他不相关药物的敏感性（附带敏感性）。在这里，我们探讨这项新兴研究如何为耐药机制带来新的启示，以及如何利用它来开发替代抗菌策略。
