抗生素耐药微生物的 collateral 敏感性 。 注：这里“collateral”可能是专业术语中特定的概念，不太常见的词汇，可能存在更准确的专业释义，如果结合更具体的上下文或许能更精准翻译。
Collateral sensitivity of antibiotic-resistant microbes.
作者信息
Pál Csaba, Papp Balázs, Lázár Viktória
机构信息
Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary.
Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary.
出版信息
Trends Microbiol. 2015 Jul;23(7):401-7. doi: 10.1016/j.tim.2015.02.009. Epub 2015 Mar 25.
Abstract
Understanding how evolution of microbial resistance towards a given antibiotic influences susceptibility to other drugs is a challenge of profound importance. By combining laboratory evolution, genome sequencing, and functional analyses, recent works have charted the map of evolutionary trade-offs between antibiotics and have explored the underlying molecular mechanisms. Strikingly, mutations that caused multidrug resistance in bacteria simultaneously enhanced sensitivity to many other unrelated drugs (collateral sensitivity). Here, we explore how this emerging research sheds new light on resistance mechanisms and the way it could be exploited for the development of alternative antimicrobial strategies.
摘要
了解微生物对特定抗生素的耐药性进化如何影响对其他药物的敏感性是一项极其重要的挑战。通过结合实验室进化、基因组测序和功能分析，近期的研究绘制了抗生素之间进化权衡的图谱，并探索了潜在的分子机制。引人注目的是，导致细菌多药耐药的突变同时增强了对许多其他不相关药物的敏感性（附带敏感性）。在这里，我们探讨这项新兴研究如何为耐药机制带来新的启示，以及如何利用它来开发替代抗菌策略。
相似文献
1
Collateral sensitivity of antibiotic-resistant microbes.
Trends Microbiol. 2015 Jul;23(7):401-7. doi: 10.1016/j.tim.2015.02.009. Epub 2015 Mar 25.
2
Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects.
Mol Biol Evol. 2017 Sep 1;34(9):2229-2244. doi: 10.1093/molbev/msx158.
3
Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network.
Nat Commun. 2014 Jul 8;5:4352. doi: 10.1038/ncomms5352.
4
Antimicrobial Peptide Exposure Selects for Resistant and Fit Stenotrophomonas maltophilia Mutants That Show Cross-Resistance to Antibiotics.
mSphere. 2020 Sep 30;5(5):e00717-20. doi: 10.1128/mSphere.00717-20.
5
Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance.
PLoS Biol. 2019 Oct 25;17(10):e3000515. doi: 10.1371/journal.pbio.3000515. eCollection 2019 Oct.
6
Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides.
Nat Microbiol. 2018 Jun;3(6):718-731. doi: 10.1038/s41564-018-0164-0. Epub 2018 May 24.
7
Using experimental evolution to identify druggable targets that could inhibit the evolution of antimicrobial resistance.
J Antibiot (Tokyo). 2018 Feb;71(2):279-286. doi: 10.1038/ja.2017.108. Epub 2017 Sep 20.
8
Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in .
mBio. 2017 Oct 31;8(5):e00517-17. doi: 10.1128/mBio.00517-17.
9
Antibiotic tolerance facilitates the evolution of resistance.
Science. 2017 Feb 24;355(6327):826-830. doi: 10.1126/science.aaj2191. Epub 2017 Feb 9.
10
Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance.
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5726-E5735. doi: 10.1073/pnas.1801646115. Epub 2018 Jun 5.
引用本文的文献
1
Cryptic phenotypic variation emerges rapidly during the adaptive evolution of a carbapenemase.
Nat Ecol Evol. 2025 Jul 30. doi: 10.1038/s41559-025-02804-6.
2
Cross-talk between Pseudomonas aeruginosa and urinary tract infections.
World J Urol. 2025 Jun 20;43(1):380. doi: 10.1007/s00345-025-05758-3.
3
Collateral sensitivity and cross-resistance in six species of bacteria exposed to six classes of antibiotics.
Microbiol Spectr. 2025 Aug 5;13(8):e0098325. doi: 10.1128/spectrum.00983-25. Epub 2025 Jun 20.
4
Ciprofloxacin resistance rapidly declines in nfxB defective clinical strains of Pseudomonas aeruginosa.
Nat Commun. 2025 Jun 4;16(1):4992. doi: 10.1038/s41467-025-60330-2.
5
Multiple Stressors in the Anthropocene: Urban Evolutionary History Modifies Sensitivity to the Toxic Effects of Crude Oil Exposure in Killifish.
Evol Appl. 2025 May 15;18(5):e70112. doi: 10.1111/eva.70112. eCollection 2025 May.
6
Leveraging collateral sensitivity to counteract the evolution of bacteriophage resistance in bacteria.
mLife. 2025 Mar 18;4(2):143-154. doi: 10.1002/mlf2.70003. eCollection 2025 Apr.
7
Invariant set theory for predicting potential failure of antibiotic cycling.
Infect Dis Model. 2025 Apr 7;10(3):897-908. doi: 10.1016/j.idm.2025.04.001. eCollection 2025 Sep.
8
Meeting Report on the Symposium "Evolutionary Applications" at the 3rd Joint Congress on Evolutionary Biology.
Evol Appl. 2025 Mar 25;18(3):e70082. doi: 10.1111/eva.70082. eCollection 2025 Mar.
9
Cell-free synthetic biology for natural product biosynthesis and discovery.
Chem Soc Rev. 2025 May 6;54(9):4314-4352. doi: 10.1039/d4cs01198h.
10
Multiple stressors in the Anthropocene: Urban evolutionary history modifies sensitivity to the toxic effects of crude oil exposure in killifish.
bioRxiv. 2025 Feb 28:2025.02.25.640141. doi: 10.1101/2025.02.25.640141.
本文引用的文献
1
Prediction of antibiotic resistance by gene expression profiles.
Nat Commun. 2014 Dec 17;5:5792. doi: 10.1038/ncomms6792.
2
Prediction of resistance development against drug combinations by collateral responses to component drugs.
Sci Transl Med. 2014 Nov 12;6(262):262ra156. doi: 10.1126/scitranslmed.3009940.
3
Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance.
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14494-9. doi: 10.1073/pnas.1409800111. Epub 2014 Sep 22.
4
Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network.
Nat Commun. 2014 Jul 8;5:4352. doi: 10.1038/ncomms5352.
5
Opposing effects of target overexpression reveal drug mechanisms.
Nat Commun. 2014 Jul 1;5:4296. doi: 10.1038/ncomms5296.
6
Strength of selection pressure is an important parameter contributing to the complexity of antibiotic resistance evolution.
Mol Biol Evol. 2014 Sep;31(9):2387-401. doi: 10.1093/molbev/msu191. Epub 2014 Jun 24.
7
Collateral damage.
Nat Biotechnol. 2014 Jan;32(1):66-8. doi: 10.1038/nbt.2779.
8
Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance.
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804. doi: 10.1073/pnas.1320886110. Epub 2013 Dec 31.
9
Fitness trade-offs restrict the evolution of resistance to amphotericin B.
PLoS Biol. 2013 Oct;11(10):e1001692. doi: 10.1371/journal.pbio.1001692. Epub 2013 Oct 29.
10
Bacterial evolution of antibiotic hypersensitivity.
Mol Syst Biol. 2013 Oct 29;9:700. doi: 10.1038/msb.2013.57.
Zotero 插件