Nathoo Nabeela, Zeydan Burcu, Neyal Nur, Chelf Cynthia, Okuda Darin T, Kantarci Orhun H
Division of Multiple Sclerosis and Autoimmune Neurology, Department of Neurology, Mayo Clinic, Rochester, MN, United States.
Department of Radiology, Mayo Clinic, Rochester, MN, United States.
Front Neurol. 2023 Jun 28;14:1215774. doi: 10.3389/fneur.2023.1215774. eCollection 2023.
Those of African American or Latin American descent have been demonstrated to have more severe clinical presentations of multiple sclerosis (MS) than non-Latin American White people with MS. Concurrently, radiological burden of disease on magnetic resonance imaging (MRI) in African Americans with MS has also been described as being more aggressive. Here, we review MRI studies in diverse racial and ethnic groups (adult and pediatric) investigating lesion burden, inflammation, neurodegeneration, and imaging response to disease modifying therapy. We also discuss why such disparities may exist beyond biology, and how future studies may provide greater insights into underlying differences.
有研究表明，非裔美国人和拉丁裔美国人患多发性硬化症（MS）的临床表现比非拉丁裔白人MS患者更为严重。同时，MS非裔美国人的磁共振成像（MRI）显示的疾病影像学负担也更为严重。在此，我们回顾了针对不同种族和族裔群体（成人和儿童）的MRI研究，这些研究调查了病变负担、炎症、神经退行性变以及疾病修饰治疗的影像学反应。我们还讨论了为何这种差异可能不仅仅存在于生物学因素，以及未来的研究如何能更深入地洞察潜在差异。
