Department of Neurology, NYU Langone Medical Center, New York, NY, USA.
Department of Pathology, NYU Langone Medical Center, New York, NY, USA.
Mult Scler Relat Disord. 2022 Jul;63:103830. doi: 10.1016/j.msard.2022.103830. Epub 2022 Apr 25.
This retrospective, single-center study aimed to characterize and compare the kinetics of B-cell reemergence following anti-CD20 infusion (anti-CD20i) in African American (AA) and white patients with MS or NMOSD. In a logistic regression model that included race, time since anti-CD20i, body mass index, and diagnosis, only AA race (p=0.01) and time since anti-CD20i (p=0.0003) were significant predictors of B-cell repletion. However, B-cell subset composition was similar between AA and white patients with detectable CD19+ B-cell counts. These findings highlight the importance of including a diverse study population in future studies of anti-CD20 therapies.
本回顾性单中心研究旨在描述和比较抗 CD20 输注（抗 CD20i）后非洲裔美国（AA）和白人患者多发性硬化症或 NMOSD 患者 B 细胞再出现的动力学。在包含种族、抗 CD20i 后时间、体重指数和诊断的逻辑回归模型中，只有 AA 种族（p=0.01）和抗 CD20i 后时间（p=0.0003）是 B 细胞补充的显著预测因子。然而，在可检测到 CD19+B 细胞计数的 AA 和白人患者中，B 细胞亚群组成相似。这些发现强调了在未来抗 CD20 治疗研究中纳入多样化研究人群的重要性。
