Bisballe S, Buus S, Lund B, Hessov I
Hum Nutr Clin Nutr. 1986 Jul;40(4):301-8.
Food intake and nutritional status was studied in 67 patients, who had had a gastrectomy 2-30 years earlier, and in a randomly selected, matched group of healthy persons. The gastrectomized patients weighed less than the control persons (women 56.4 +/- 9.5 vs 61.4 +/- 6.9 kg; P less than 0.05; men 72.4 +/- 12.5 vs 77.7 +/- 9.2 kg; P less than 0.02). Compared to the controls the gastrectomized women had a significantly lower fat-free mass (37.8 +/- 4.1 vs 40.7 +/- 4.3 kg; P less than 0.02), whereas the gastrectomized men had a lower fat mass (17.0 +/- 7.8 vs 21.2 +/- 6.0 kg; P less than 0.01). The serum concentration of alkaline phosphatase was raised and the concentration of calcium, phosphorus and 25-hydroxycholecalciferol reduced in the gastrectomized group. None of these results could be explained from the nutritional study as both the intake of energy and protein and the intake of calcium and vitamin D was about the same in the operated and the healthy controls. The serum concentration of 25-hydroxycholecalciferol was significantly higher in the gastrectomized persons taking supplementary vitamin D (21.9 +/- 12.0 vs 11.7 +/- 6.5 ng/ml). A daily supplement of 10 micrograms of vitamin D secured normal serum values. As the serum level of 25-hydroxycholecalciferol is correlated to the degree of osteomalacia, all gastrectomized patients should have at least 10 micrograms vitamin D as a supplement once a day.
对67例2至30年前接受过胃切除术的患者以及一组随机选取的、年龄匹配的健康人进行了食物摄入量和营养状况研究。接受胃切除术的患者体重低于对照组(女性:56.4±9.5kg对61.4±6.9kg;P<0.05;男性:72.4±12.5kg对77.7±9.2kg;P<0.02)。与对照组相比,接受胃切除术的女性去脂体重显著更低(37.8±4.1kg对40.7±4.3kg;P<0.02),而接受胃切除术的男性脂肪量更低(17.0±7.8kg对21.2±6.0kg;P<0.01)。接受胃切除术组的血清碱性磷酸酶浓度升高,钙、磷和25-羟胆钙化醇浓度降低。这些结果均无法从营养研究中得到解释,因为手术组和健康对照组的能量、蛋白质摄入量以及钙和维生素D的摄入量大致相同。服用补充维生素D的接受胃切除术者的血清25-羟胆钙化醇浓度显著更高(21.9±12.0对11.7±6.5ng/ml)。每日补充10微克维生素D可使血清值正常。由于血清25-羟胆钙化醇水平与骨软化程度相关,所有接受胃切除术的患者每天都应至少补充10微克维生素D。