Kowall Bernd, Kostev Karel, Landgraf Rüdiger, Hauner Hans, Bierwirth Ralf, Kuss Oliver, Rathmann Wolfgang
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Germany.
Epidemiology, IQVIA, Frankfurt/Main, Germany.
Vaccine X. 2023 Jun 24;14:100336. doi: 10.1016/j.jvacx.2023.100336. eCollection 2023 Aug.
We investigated whether COVID-19 vaccination had an impact on diabetes risk.
We used data of 6,198 patients (mean age 64.3 years) from the nationwide Disease Analyzer database, a representative panel of physicians' practices in Germany. Patients received their first COVID-19 vaccination between 1 April 2021 and 31 March 2022, and all were newly diagnosed with diabetes within 183 days before or after this vaccination. Incident rates of diabetes after vaccination were compared to incident rates before vaccination.
The incidence rate of diabetes was lower after vaccination than before vaccination (incidence rate ratio = 0.79, 95% confidence interval: 0.75-0.83). The number of incident cases of diabetes was not greater in 2021 than in 2019.
Our study did not confirm an increased risk of diabetes after COVID-19 vaccination. Further studies are needed to show whether the vaccination may be associated with a reduced diabetes risk.
我们调查了新冠病毒疫苗接种是否对糖尿病风险有影响。
我们使用了来自德国全国疾病分析器数据库的6198名患者（平均年龄64.3岁）的数据，该数据库是德国医生执业情况的代表性样本。患者在2021年4月1日至2022年3月31日期间接种了第一剂新冠病毒疫苗，且所有患者均在此次疫苗接种前或后的183天内被新诊断为糖尿病。将疫苗接种后的糖尿病发病率与接种前的发病率进行比较。
接种疫苗后的糖尿病发病率低于接种前（发病率比=0.79，95%置信区间：0.75-0.83）。2021年糖尿病的新发病例数并不多于2019年。
我们的研究未证实新冠病毒疫苗接种后糖尿病风险增加。需要进一步研究以表明疫苗接种是否可能与糖尿病风险降低相关。
