Halevy A, Strohm G, Wieczorek U
HNO. 1986 Jul;34(7):285-90.
Twenty-nine patients affected by typical unilateral sudden hearing loss were treated with Xantinolnicotinate (Complamin) by a 21 days infusion of 1.5 g-30 g in 500 ml NaCl 0.9% followed by 3 months 1,000 mg sustained release tablets t.i.d. An improvement in hearing was achieved in 90.5% of the cases and in 52% returned to normal. Tinnitus improved in 92% of cases and resolved completely in 54%. The results of speech and sound audiograms correlated well, and showed significant recovery in the first 3 weeks. The infusion therapy was terminated prematurely in 4 patients because of near normalization of hearing (maximum dosage: 15 g Complamin). Adverse reactions only occurred during the infusion therapy. For ethical and therapeutic reasons a placebo control group was not included. To compensate for this the audiograms of impaired and 'normal' ears were compared. The changes in hearing and tinnitus are therefore to be regarded as the result of spontaneous remission and drug efficacy.
29例典型单侧突发性听力损失患者接受了烟酸占替诺（康脑灵）治疗，先在500毫升0.9%氯化钠溶液中输注1.5克至30克，持续21天，随后服用3个月的1000毫克缓释片，每日3次。90.5%的病例听力得到改善，52%恢复正常。92%的病例耳鸣有所改善，54%完全消失。言语和纯音听力图结果相关性良好，且在前3周显示出显著恢复。4例患者因听力接近正常（最大剂量：15克康脑灵）而提前终止输注治疗。不良反应仅发生在输注治疗期间。出于伦理和治疗原因，未设安慰剂对照组。为此，对患侧和“正常”耳的听力图进行了比较。因此，听力和耳鸣的变化应被视为自发缓解和药物疗效的结果。
