McKenna Brooke G, Dunlop Anne L, Corwin Elizabeth, Smith Alicia K, Venkateswaran Suresh, Brennan Patricia A
Department of Psychology, Emory University, Atlanta, GA, 30322, USA.
School of Nursing, Emory University, Atlanta, GA, 30322, USA.
Brain Behav Immun Health. 2023 Jun 15;31:100651. doi: 10.1016/j.bbih.2023.100651. eCollection 2023 Aug.
Recent evidence suggests that maternal childhood adversity may have an intergenerational impact, with children of adversity-exposed mothers exhibiting elevated symptoms of psychopathology. At the same time, many children demonstrate resilience to these intergenerational effects. Among the variety of factors that likely contribute to resilience, the composition of the gut microbiome may play a role in buffering the negative impacts of trauma and stress. The current prospective cohort study tested the novel hypothesis that offspring gut microbiome composition is a potential moderator in the relationship between maternal exposure to childhood adversity and offspring symptomatology (i.e., internalizing, externalizing, and posttraumatic stress symptoms). Maternal childhood adversity was self-reported during pregnancy via the Childhood Trauma Questionnaire and Adverse Childhood Experiences (ACEs) survey, and offspring symptomatology was assessed with the Child Behavior Checklist/1.5-5 when offspring were 2-4 years old. Offspring fecal samples were collected between these timepoints (i.e., during 6- to 24-month follow-up visits) for microbiome sequencing. Results indicated that maternal ACEs and the relative abundances of , , and were associated with offspring symptomatology. However, there was little evidence that microbial abundance moderated the association between maternal adversity and offspring symptoms. Overall, these findings further our understanding of how the gut microbiome associates with psychopathology, and informs future studies aimed at targeting modifiable factors that may buffer the intergenerational effects of childhood adversity.
最近的证据表明，母亲童年时期的逆境可能会产生代际影响，母亲曾经历逆境的孩子表现出更高的精神病理学症状。与此同时，许多孩子对这些代际影响具有恢复力。在可能有助于恢复力的各种因素中，肠道微生物群的组成可能在缓冲创伤和压力的负面影响方面发挥作用。当前的前瞻性队列研究检验了一个新假设，即后代肠道微生物群组成是母亲童年时期经历逆境与后代症状（即内化、外化和创伤后应激症状）之间关系的潜在调节因素。通过《童年创伤问卷》和《童年不良经历》（ACEs）调查在孕期自我报告母亲童年时期的逆境情况，在后代2至4岁时用《儿童行为检查表》/1.5 - 5评估后代症状。在这些时间点之间（即6至24个月的随访期间）收集后代粪便样本进行微生物群测序。结果表明，母亲的ACEs以及[此处原文缺失具体菌种名称]、[此处原文缺失具体菌种名称]和[此处原文缺失具体菌种名称]的相对丰度与后代症状有关。然而，几乎没有证据表明微生物丰度调节了母亲逆境与后代症状之间的关联。总体而言，这些发现进一步加深了我们对肠道微生物群与精神病理学之间关联的理解，并为未来旨在针对可能缓冲童年逆境代际影响的可改变因素的研究提供了信息。
