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TREM2 as an evolving therapeutic target in Alzheimer's disease.

作者信息

George Jacob

机构信息

Cognyxx Pharmaceuticals, Tel Aviv Israel and Kaplan Heart Center, Rehovot, Israel.

出版信息

Neural Regen Res. 2023 Dec;18(12):2680-2681. doi: 10.4103/1673-5374.371360.

DOI:10.4103/1673-5374.371360
PMID:37449620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10358665/
Abstract
摘要

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Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease.持续稳定的 Trem2 可加速阿尔茨海默病小鼠模型中小胶质细胞的异质性和 Aβ 病理。
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Treadmill exercise improve recognition memory by TREM2 pathway to inhibit hippocampal microglial activation and neuroinflammation in Alzheimer's disease model.跑步机运动通过 TREM2 通路改善阿尔茨海默病模型中的识别记忆，抑制海马小胶质细胞激活和神经炎症。
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The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein Stability.与阿尔茨海默病相关的TREM2基因R47H变异体具有改变的糖基化模式和蛋白质稳定性。
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Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles.TREM2 在阿尔茨海默病中的作用及其对β-淀粉样蛋白、tau 和神经原纤维缠结的影响。
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Alzheimers Dement. 2025 Feb;21(2):e14548. doi: 10.1002/alz.14548. Epub 2025 Jan 27.
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A Computational Approach in the Systematic Search of the Interaction Partners of Alternatively Spliced TREM2 Isoforms.一种在系统搜索 TREM2 异构体的互作伙伴中的计算方法。
Int J Mol Sci. 2024 Sep 6;25(17):9667. doi: 10.3390/ijms25179667.
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Microglia, Trem2, and Neurodegeneration.小胶质细胞、TREM2与神经退行性变
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本文引用的文献

1
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading.慢性 TREM2 激活加剧了 Aβ 相关 tau 种子的形成和传播。
J Exp Med. 2023 Jan 2;220(1). doi: 10.1084/jem.20220654. Epub 2022 Oct 11.
2
The Primary Microglial Leukodystrophies: A Review.原发性小胶质细胞脑白质营养不良：综述。
Int J Mol Sci. 2022 Jun 6;23(11):6341. doi: 10.3390/ijms23116341.
3
Soluble TREM2: Innocent bystander or active player in neurological diseases?可溶性 TREM2：神经疾病中的无辜旁观者还是活跃参与者？
Neurobiol Dis. 2022 Apr;165:105630. doi: 10.1016/j.nbd.2022.105630. Epub 2022 Jan 15.
4
Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models.新型单克隆抗体与 TREM2 结合可诱导小胶质细胞活化，并改善阿尔茨海默病模型的认知功能。
J Neuroinflammation. 2021 Jan 9;18(1):19. doi: 10.1186/s12974-020-01980-5.
5
Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition.治疗性激活Trem2可改善淀粉样蛋白沉积的5XFAD模型中的β-淀粉样蛋白沉积并提高认知能力。
J Neuroinflammation. 2020 Aug 14;17(1):238. doi: 10.1186/s12974-020-01915-0.
6
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.抗人 TREM2 诱导小胶质细胞增殖并减少阿尔茨海默病模型中的病理。
J Exp Med. 2020 Sep 7;217(9). doi: 10.1084/jem.20200785.
7
The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway.TREM2 信号通路的生理学、病理学和潜在治疗应用。
Cell. 2020 Jun 11;181(6):1207-1217. doi: 10.1016/j.cell.2020.05.003.
8
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.利用针对茎区的双功能TREM2抗体增强小胶质细胞的保护活性。
EMBO Mol Med. 2020 Apr 7;12(4):e11227. doi: 10.15252/emmm.201911227. Epub 2020 Mar 10.
9
TREM2 - a key player in microglial biology and Alzheimer disease.TREM2 - 小胶质细胞生物学和阿尔茨海默病的关键因素。
Nat Rev Neurol. 2018 Nov;14(11):667-675. doi: 10.1038/s41582-018-0072-1.
10
TREM2 variants in Alzheimer's disease.TREM2 变体在阿尔茨海默病中的作用。
N Engl J Med. 2013 Jan 10;368(2):117-27. doi: 10.1056/NEJMoa1211851. Epub 2012 Nov 14.