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TREM2 as an evolving therapeutic target in Alzheimer's disease.

作者信息

George Jacob

机构信息

Cognyxx Pharmaceuticals, Tel Aviv Israel and Kaplan Heart Center, Rehovot, Israel.

出版信息

Neural Regen Res. 2023 Dec;18(12):2680-2681. doi: 10.4103/1673-5374.371360.

Abstract
摘要

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本文引用的文献

1
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading.
J Exp Med. 2023 Jan 2;220(1). doi: 10.1084/jem.20220654. Epub 2022 Oct 11.
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The Primary Microglial Leukodystrophies: A Review.
Int J Mol Sci. 2022 Jun 6;23(11):6341. doi: 10.3390/ijms23116341.
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Soluble TREM2: Innocent bystander or active player in neurological diseases?
Neurobiol Dis. 2022 Apr;165:105630. doi: 10.1016/j.nbd.2022.105630. Epub 2022 Jan 15.
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The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway.
Cell. 2020 Jun 11;181(6):1207-1217. doi: 10.1016/j.cell.2020.05.003.
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Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
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TREM2 - a key player in microglial biology and Alzheimer disease.
Nat Rev Neurol. 2018 Nov;14(11):667-675. doi: 10.1038/s41582-018-0072-1.
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TREM2 variants in Alzheimer's disease.
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