新冠大流行第一年巴西公立医院的抗生素配给情况。

Antibiotic dispensing during first year of COVID-19 pandemic in Brazilian public hospitals.

机构信息

Health Sciences Center, Federal University of Espírito Santo, Av. Marechal Campos, 1468, Vitória, Espírito Santo, 29040-090, Brazil.

出版信息

Future Microbiol. 2023 Jul;18:639-647. doi: 10.2217/fmb-2022-0255. Epub 2023 Jul 14.

DOI:10.2217/fmb-2022-0255

PMID:37449879

Abstract

To evaluate the impact of the first year of the COVID-19 pandemic on antibiotic dispensation in three Brazilian hospitals. Stock movement was accessed from pharmacy databases and microbiological reports from 2018 to 2021. Reduced antibiotic dispensation occurred during 2020 in all hospitals. The most significant reduction was in April at Hospital Doutor Jayme dos Santos Neves (∼58%), and in May at Hospital Doutor Roberto Arnizaut Silvares (∼66%) and Hospital Doutor Dório Silva (∼29%). However, azithromycin dispensation increased in all hospitals in 2020. Macrolide-resistant bacterial isolates rose from 66.6% in 2019 to 77.1% in 2020 and 88.3% in 2021. Despite reduced antibiotic dispensation, the increase in azithromycin consumption in 2020 highlights the urgency to monitor macrolide resistance after the pandemic and improve stewardship activities.

摘要

评估 COVID-19 大流行第一年对巴西三家医院抗生素配药的影响。从 2018 年至 2021 年，我们从药房数据库和微生物学报告中获取了库存变动情况。所有医院在 2020 年均出现了抗生素配药减少的情况。在 Hospital Doutor Jayme dos Santos Neves（约 58%），抗生素配药减少幅度最大的是在 4 月，在 Hospital Doutor Roberto Arnizaut Silvares（约 66%）和 Hospital Doutor Dório Silva（约 29%），则是在 5 月。然而，2020 年所有医院的阿奇霉素配药量都有所增加。大环内酯类耐药细菌的分离株从 2019 年的 66.6%上升到 2020 年的 77.1%和 2021 年的 88.3%。尽管抗生素配药减少，但 2020 年阿奇霉素用量增加突出表明在大流行后需要监测大环内酯类耐药情况，并加强管理活动。