Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30566. doi: 10.1002/pbc.30566. Epub 2023 Jul 14.
The Children's Oncology Group (COG) Epidemiology Committee has a primary focus on better understanding the etiologies of childhood cancers. Over the past 10 years, the committee has leveraged the Childhood Cancer Research Network, and now more recently Project:EveryChild (PEC), to conduct epidemiologic assessments of various childhood cancers, including osteosarcoma, neuroblastoma, germ cell tumors, Ewing sarcoma, rhabdomyosarcoma, and Langerhans cell histiocytosis. More recent studies have utilized questionnaire data collected as part of PEC to focus on specific characteristics and/or features, including the presence of congenital disorders and the availability of stored cord blood. Members of the COG Epidemiology Committee have also been involved in other large-scale National Institutes of Health efforts, including the Childhood Cancer Data Initiative and the Gabriella Miller Kids First Pediatric Research Program, which are improving our understanding of the factors associated with childhood cancer risk. Future plans will focus on addressing questions surrounding health disparities, utilizing novel biospecimens in COG epidemiology studies, exploring the role of environmental factors on the etiologies and outcomes of childhood cancer, collaborating with other COG committees to expand the role of epidemiology in childhood cancer research, and building new epidemiologic studies from the Molecular Characterization Initiative-all with the ultimate goal of developing novel prevention and intervention strategies for childhood cancer.
儿童肿瘤学组（COG）流行病学委员会的主要关注点是更好地了解儿童癌症的病因。在过去的 10 年中，该委员会利用儿童癌症研究网络，现在更多地利用“每个孩子”项目（PEC），对各种儿童癌症（包括骨肉瘤、神经母细胞瘤、生殖细胞瘤、尤文肉瘤、横纹肌肉瘤和朗格汉斯细胞组织细胞增生症）进行了流行病学评估。最近的研究利用 PEC 收集的问卷调查数据，重点关注特定的特征和/或特征，包括先天性疾病的存在和储存脐带血的可用性。COG 流行病学委员会的成员还参与了其他大规模的美国国立卫生研究院的努力，包括儿童癌症数据倡议和加布里埃拉·米勒儿童第一儿科研究计划，这些努力提高了我们对与儿童癌症风险相关因素的理解。未来的计划将侧重于解决与健康差异相关的问题，在 COG 流行病学研究中利用新型生物样本，探索环境因素对儿童癌症病因和结果的作用，与其他 COG 委员会合作扩大流行病学在儿童癌症研究中的作用，以及从分子特征倡议中建立新的流行病学研究-所有这些最终目标都是为儿童癌症制定新的预防和干预策略。
