肿瘤学临床试验中纳入健康社会决定因素评估的可行性。
Feasibility of oncology clinical trial-embedded evaluation of social determinants of health.
作者信息
Aziz-Bose Rahela, Zheng Daniel J, Umaretiya Puja J, Ilcisin Lenka, Stevenson Kristen, Koch Victoria, Valenzuela Ariana, Cole Peter D, Gennarini Lisa M, Kahn Justine M, Kelly Kara M, Tran Thai-Hoa, Michon Bruno, Welch Jennifer J G, Silverman Lewis B, Wolfe Joanne, Bona Kira
机构信息
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA.
出版信息
Pediatr Blood Cancer. 2022 Nov;69(11):e29933. doi: 10.1002/pbc.29933. Epub 2022 Sep 7.
Abstract
Social determinants of health (SDoH) are associated with stark disparities in cancer outcomes, but systematic SDoH data collection is virtually absent from oncology clinical trials. Trial-based SDoH data are essential to ensure representation of marginalized populations, contextualize outcome disparities, and identify health-equity intervention opportunities. We report the feasibility of a pediatric oncology multicenter therapeutic trial-embedded SDoH investigation. Among 448 trial participants, 392 (87.5%) opted-in to the embedded SDoH study; 375 (95.7%) completed baseline surveys, with high longitudinal response rates (88.9-93.1%) over 24 months. Trial-embedded SDoH data collection is feasible and acceptable and must be consistently included within future oncology trials.
摘要
健康的社会决定因素（SDoH）与癌症治疗结果的巨大差异相关，但肿瘤学临床试验几乎没有系统收集SDoH数据。基于试验的SDoH数据对于确保边缘化人群的代表性、解释结果差异以及确定健康公平干预机会至关重要。我们报告了一项儿科肿瘤多中心治疗试验嵌入式SDoH调查的可行性。在448名试验参与者中，392名（87.5%）选择参与嵌入式SDoH研究；375名（95.7%）完成了基线调查，在24个月内纵向应答率较高（88.9 - 93.1%）。试验嵌入式SDoH数据收集是可行且可接受的，必须始终纳入未来的肿瘤学试验中。
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