Aziz-Bose Rahela, Zheng Daniel J, Umaretiya Puja J, Ilcisin Lenka, Stevenson Kristen, Koch Victoria, Valenzuela Ariana, Cole Peter D, Gennarini Lisa M, Kahn Justine M, Kelly Kara M, Tran Thai-Hoa, Michon Bruno, Welch Jennifer J G, Silverman Lewis B, Wolfe Joanne, Bona Kira
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA.
Pediatr Blood Cancer. 2022 Nov;69(11):e29933. doi: 10.1002/pbc.29933. Epub 2022 Sep 7.
Social determinants of health (SDoH) are associated with stark disparities in cancer outcomes, but systematic SDoH data collection is virtually absent from oncology clinical trials. Trial-based SDoH data are essential to ensure representation of marginalized populations, contextualize outcome disparities, and identify health-equity intervention opportunities. We report the feasibility of a pediatric oncology multicenter therapeutic trial-embedded SDoH investigation. Among 448 trial participants, 392 (87.5%) opted-in to the embedded SDoH study; 375 (95.7%) completed baseline surveys, with high longitudinal response rates (88.9-93.1%) over 24 months. Trial-embedded SDoH data collection is feasible and acceptable and must be consistently included within future oncology trials.
健康的社会决定因素（SDoH）与癌症治疗结果的巨大差异相关，但肿瘤学临床试验几乎没有系统收集SDoH数据。基于试验的SDoH数据对于确保边缘化人群的代表性、解释结果差异以及确定健康公平干预机会至关重要。我们报告了一项儿科肿瘤多中心治疗试验嵌入式SDoH调查的可行性。在448名试验参与者中，392名（87.5%）选择参与嵌入式SDoH研究；375名（95.7%）完成了基线调查，在24个月内纵向应答率较高（88.9 - 93.1%）。试验嵌入式SDoH数据收集是可行且可接受的，必须始终纳入未来的肿瘤学试验中。
