液体活检在肝细胞癌中的应用。

Liquid Biopsy in Hepatocellular Carcinoma.

机构信息

Department of General Surgery, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, Nanjing, China.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

出版信息

Methods Mol Biol. 2023;2695:213-225. doi: 10.1007/978-1-0716-3346-5_14.

DOI:10.1007/978-1-0716-3346-5_14

PMID:37450121

Abstract

Hepatocellular carcinoma (HCC) is one of the most deadly neoplasms with a poor prognosis. Due to the significant tumor heterogeneity of HCC, alpha-fetoprotein (AFP) or liver biopsy has not yet met the clinical needs in terms of early diagnosis or determining prognosis. In recent years, liquid biopsy techniques that analyze tumor by-products released into the circulation have shown great potential. Its ability to monitor tumors in real time and respond to their global characteristics is expected to improve the management of HCC patients clinically. This review discusses some of the findings of a liquid biopsy in terms of diagnosis and prognosis of HCC.

摘要

肝细胞癌（HCC）是预后最差的恶性肿瘤之一。由于 HCC 存在明显的肿瘤异质性，甲胎蛋白（AFP）或肝活检尚不能满足早期诊断或确定预后的临床需求。近年来，通过分析释放到循环系统中的肿瘤产物来分析肿瘤的液体活检技术显示出巨大的潜力。其实时监测肿瘤并对其整体特征做出反应的能力有望改善 HCC 患者的临床管理。本文就液体活检在 HCC 诊断和预后方面的一些发现进行综述。