Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Methods Mol Biol. 2023;2695:295-308. doi: 10.1007/978-1-0716-3346-5_20.
Liquid biopsy is an emergent test method for the diagnosis and prognosis in the clinic. Joint fluid, also known as synovial fluid, contains a variety of bioactive constituents that can be selectively detected and further evaluated in a convenient fashion. Therefore, synovial fluid analysis functions as a specific form of liquid biopsy and plays a vital role in numerous joint diseases. In spite of the component analysis of aspirated synovial fluid beingconsidered as the gold standard for diagnosis of joint infections, biopsy of joint fluid benefits the initial diagnosis and long-term prognosis of degenerative, inflammatory, autoimmune, traumatic, congenital, and even neoplastic joint diseases. The convenience and accuracy for disease evaluation are significantly elevated as a result of the combination of synovial fluid analysis and other novel clinical technologies. In this review, we shed light on the latent role of synovial fluid in the diagnosis and prognosis of articular diseases and proposed future prospects for relevant research in this field.
液体活检是临床诊断和预后的一种新兴检测方法。关节液，也称为滑液，含有多种生物活性成分，可以以方便的方式进行选择性检测和进一步评估。因此，滑膜液分析作为一种特殊形式的液体活检，在许多关节疾病中发挥着重要作用。尽管关节液抽吸的成分分析被认为是关节感染诊断的金标准，但关节液活检有利于退行性、炎症性、自身免疫性、外伤性、先天性，甚至肿瘤性关节疾病的初步诊断和长期预后。由于滑膜液分析与其他新型临床技术的结合，疾病评估的便利性和准确性显著提高。在这篇综述中，我们探讨了关节液在关节疾病诊断和预后中的潜在作用，并对该领域的相关研究提出了未来展望。
