Certara UK, Sheffield, UK.
Leiden Academic Centre for Drug Research, Universiteit Leiden, Leiden, the Netherlands.
CPT Pharmacometrics Syst Pharmacol. 2023 Jul;12(7):889-903. doi: 10.1002/psp4.12972. Epub 2023 May 4.
Typical Quantitative Systems Pharmacology (QSP) workflows involve discussion of biology, supported by graphical diagrams, followed by construction of large Ordinary Differential Equation models. QSP Designer facilitates this process by providing enhanced graphical notation, which enables hierarchical presentation with modules and handling of combinatorial complexity with diagram node arrays. Whereas the software includes a simulation engine, a major feature is full model code generation in MATLAB, R, C, and Julia to support multiple modeling communities.
典型的定量系统药理学 (QSP) 工作流程涉及生物学讨论,辅以图形图表,然后构建大型常微分方程模型。QSP Designer 通过提供增强的图形符号来促进这一过程,这使得模块具有层次化表示,并且可以使用图表节点数组来处理组合复杂性。虽然该软件包括一个仿真引擎,但一个主要特点是在 MATLAB、R、C 和 Julia 中完全生成模型代码,以支持多个建模社区。