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一种用于系统药理学稳健应用的六阶段工作流程。

A Six-Stage Workflow for Robust Application of Systems Pharmacology.

作者信息

Gadkar K, Kirouac D C, Mager D E, van der Graaf P H, Ramanujan S

机构信息

Translational & Systems Pharmacology, PKPD, Genentech, South San Francisco, California, USA.

Department of Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York.

出版信息

CPT Pharmacometrics Syst Pharmacol. 2016 May;5(5):235-49. doi: 10.1002/psp4.12071. Epub 2016 Apr 16.

DOI:10.1002/psp4.12071
PMID:27299936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4879472/
Abstract

Quantitative and systems pharmacology (QSP) is increasingly being applied in pharmaceutical research and development. One factor critical to the ultimate success of QSP is the establishment of commonly accepted language, technical criteria, and workflows. We propose an integrated workflow that bridges conceptual objectives with underlying technical detail to support the execution, communication, and evaluation of QSP projects.

摘要

定量与系统药理学（QSP）在药物研发中的应用日益广泛。对于QSP最终取得成功至关重要的一个因素是建立普遍认可的语言、技术标准和工作流程。我们提出了一种综合工作流程，该流程将概念目标与基础技术细节相衔接，以支持QSP项目的实施、交流和评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d4/4879472/250e171f7553/PSP4-5-235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d4/4879472/442d616f27f8/PSP4-5-235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d4/4879472/60a67d866cdf/PSP4-5-235-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d4/4879472/250e171f7553/PSP4-5-235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d4/4879472/442d616f27f8/PSP4-5-235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d4/4879472/60a67d866cdf/PSP4-5-235-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47d4/4879472/250e171f7553/PSP4-5-235-g003.jpg

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