Clinical Neurosciences, University of Cambridge, Addenbrooke's Biomedical Campus, Cambridge, Cambridgshire, CB2 0QQ, UK.
Acta Neurochir (Wien). 2023 Oct;165(10):2903-2911. doi: 10.1007/s00701-023-05665-9. Epub 2023 Jul 15.
Vestibular schwannoma (VS) is the most common benign tumour arising in the lateral skull base. Reported incidence rates of VS vary across geographical locations and over time. There is scarce updated evidence over the past decade on the epidemiology and mode of presentation of VS.
To describe the epidemiology and mode of presentation of VS in the East of England between 2013 and 2016.
A retrospective epidemiological analysis of data from a national VS registry and electronic patient records was conducted, including all newly diagnosed adult patients in a UK tertiary referral centre, between April 1st, 2013, and March 31st, 2016.
There were 391 new cases identified resulting in an overall mean incidence of 2.2 VS cases per 100,000 person-year. The incidence rate for all patients in the <40 age group ranged between 0.3 and 0.7 per 100,000 person-year, increasing to a range of 5.7 to 6.1 per 100,000 person-year in the 60-69 age group. The top three combinations of symptoms on presentation per patient were hearing loss and tinnitus (97, 24.8%), hearing loss alone (79, 20.2%) and hearing loss, tinnitus, and balance symptoms (61, 15.6%). The median duration of symptoms was 12 months, with a wide range from 1.4 to 300 months. Age was negatively correlated with tumour size (r = -0.14 [-0.24 to -0.04], p=0.01) and positively correlated with symptom duration (r = 0.16 [0.03-0.29], p=0.02).
The incidence of vestibular schwannoma has increased compared to previous studies in the UK and is similar to incidence rates reported in other countries during the past decade. It peaks in the seventh decade of life, mainly because of an increase in the diagnosis of small tumours with a long duration of audio-vestibular symptoms in older patients, compared to earlier studies.
前庭神经鞘瘤（VS）是最常见的发生于颅底外侧的良性肿瘤。VS 的报告发病率在不同地理位置和不同时间存在差异。在过去十年中，关于 VS 的流行病学和表现模式的最新证据稀缺。
描述 2013 年至 2016 年间英格兰东部 VS 的流行病学和表现模式。
对国家 VS 登记处和电子患者记录中的数据进行回顾性流行病学分析，包括英国一家三级转诊中心的所有新诊断的成年患者，时间为 2013 年 4 月 1 日至 2016 年 3 月 31 日。
共确定 391 例新病例，总体平均发病率为每 100,000 人年 2.2 例 VS。<40 岁年龄组所有患者的发病率范围为每 100,000 人年 0.3 至 0.7 例，在 60-69 岁年龄组增加至每 100,000 人年 5.7 至 6.1 例。每位患者就诊时的前三种症状组合为听力损失和耳鸣（97 例，24.8%）、单纯听力损失（79 例，20.2%）和听力损失、耳鸣和平衡症状（61 例，15.6%）。症状的中位持续时间为 12 个月，范围从 1.4 至 300 个月不等。年龄与肿瘤大小呈负相关（r = -0.14 [-0.24 至 -0.04]，p=0.01），与症状持续时间呈正相关（r = 0.16 [0.03-0.29]，p=0.02）。
与英国以前的研究相比，VS 的发病率有所增加，与过去十年其他国家的发病率相似。它在生命的第七个十年达到高峰，主要是因为与早期研究相比，老年患者出现较长时间的听觉-前庭症状的小肿瘤诊断增加。
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