Department of Obstetrics and Gynaecology, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Department of Obstetrics and Gynaecology, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.
Cell Rep. 2023 Jul 25;42(7):112800. doi: 10.1016/j.celrep.2023.112800. Epub 2023 Jul 14.
The human placenta exhibits a unique genomic architecture with an unexpectedly high mutation burden and many uniquely expressed genes. The aim of this study is to identify transcripts that are uniquely absent or depleted in the placenta. Here, we show that 40 of 46 of the other organs have no selectively depleted transcripts and that, of the remaining six, the liver has the largest number, with 26. In contrast, the term placenta has 762 depleted transcripts. Gene Ontology analysis of this depleted set highlighted multiple pathways reflecting known unique elements of placental physiology. For example, transcripts associated with neuronal function are in the depleted set-as expected given the lack of placental innervation. However, this demonstrated overrepresentation of genes involved in mitochondrial function (p = 5.8 × 10), including PGC-1α, the master regulator of mitochondrial biogenesis, and genes involved in polyamine metabolism (p = 2.1 × 10).
人类胎盘表现出独特的基因组结构，具有出乎意料高的突变负担和许多独特表达的基因。本研究的目的是鉴定在胎盘组织中特异性缺失或表达下调的转录本。我们发现，在 46 个其他器官中，有 40 个没有特异性缺失的转录本，而在剩下的 6 个器官中，肝脏的缺失转录本数量最多，有 26 个。相比之下，胎盘组织有 762 个缺失转录本。对这个缺失转录本集的基因本体论分析强调了多个反映胎盘生理学独特元素的途径。例如，与神经元功能相关的转录本存在于缺失转录本集中——考虑到胎盘没有神经支配，这是意料之中的。然而，这表明参与线粒体功能的基因（p = 5.8×10）过度表达，包括线粒体生物发生的主调节因子 PGC-1α，以及参与多胺代谢的基因（p = 2.1×10）。
