Faculty of Dentistry, The University of Hong Kong, Postal address: 3/F, The Prince Philip Dental Hospital, 34, Hospital Road, Sai Ying Pun, Hong Kong, China.
Faculty of Dentistry, The University of Hong Kong, Postal address: 3/F, The Prince Philip Dental Hospital, 34, Hospital Road, Sai Ying Pun, Hong Kong, China.
J Dent. 2023 Sep;136:104616. doi: 10.1016/j.jdent.2023.104616. Epub 2023 Jul 14.
This study aimed to evaluate the desensitizing effect of topically applied 38% silver diamine fluoride (SDF) solution on the exposed root surface of hypersensitive teeth in older adults.
This double-blind randomised clinical trial recruited healthy older adults with dentine hypersensitivity. A trained examiner tested the most hypersensitive tooth root surface with a blast of compressed cold air from a three-in-one syringe. The participants gave a sensitivity score (SS) in visual analogue scale from 0 (no pain) to 10 (agonizing) at the baseline visit. Then, they received 38% SDF or 5% potassium nitrate solution (control) as intervention on the root surface. After the intervention, they received a compressed cold air test and reported the SS again. The compressed cold air test followed by intervention was repeated at 4- and 8-week follow ups. The primary outcome was the reduction in SS at 8-week follow-up with reference to the SS at baseline before intervention. Shapiro-Wilk and Mann-Whitney U tests were performed for data analysis following a normality test of SS.
This trial recruited 148 participants, and 139 (94%) participants completed the trial. The median percentage reductions in SS in the SDF and potassium nitrate groups were 60% and 50%, respectively (p < 0.001).
According to the results, 38% SDF solution reduced hypersensitivity on the exposed root surface of older adults. In addition, 38% SDF was more effective than 5% potassium nitrate solution to reduce hypersensitivity on the exposed root surface of older adults.
Dentin hypersensitivity is common amongst older adults and negatively affects their quality of life. To date, there is no gold standard professionally applied desensitizing therapy in treating hypersensitivity. Evidence from this clinical trial could aid clinical practice and improve oral health in older adults.
This study was registered at ClinicalTrials.gov (NCT05392868).
本研究旨在评估局部应用 38% 氟化银（SDF）溶液对老年人敏感牙齿暴露根面的脱敏效果。
本双盲随机临床试验招募了有牙本质敏感的健康老年人。一名经过培训的检查者使用三用注射器喷出的压缩冷空气对最敏感的牙根部表面进行测试。在基线就诊时，参与者使用视觉模拟量表（VAS）从 0（无痛）到 10（剧痛）对根面进行敏感评分（SS）。然后，他们将 38%SDF 或 5%硝酸钾溶液（对照）作为干预剂应用于根面。干预后，他们再次接受压缩冷空气测试并报告 SS。在 4 周和 8 周的随访中重复进行干预后压缩冷空气测试。主要结局是与干预前基线时的 SS 相比，8 周随访时 SS 的降低。在对 SS 进行正态性检验后，采用 Shapiro-Wilk 和 Mann-Whitney U 检验进行数据分析。
本试验共招募了 148 名参与者，其中 139 名（94%）参与者完成了试验。SDF 和硝酸钾组 SS 的中位数降低百分比分别为 60%和 50%（p<0.001）。
根据结果，38%SDF 溶液可降低老年人暴露根面的敏感性。此外，38%SDF 比 5%硝酸钾溶液更能有效降低老年人暴露根面的敏感性。
牙本质敏感在老年人中很常见，会对他们的生活质量产生负面影响。迄今为止，尚无金标准的专业应用脱敏疗法用于治疗敏感性。本临床试验的证据可以为临床实践提供帮助，并改善老年人的口腔健康。
本研究在 ClinicalTrials.gov 注册（NCT05392868）。
